Stochastic Signature Analysis

Stochastic Signature Analysis is a method for characterizing the distinctive patterns of variability and randomness within observed data, including behavioral records. It works by representing events or measurements as probabilistic features, such as frequency distributions, transition probabilities, temporal dependencies, and fluctuations across repeated observations, then comparing these signatures with reference data or statistical models. In behavior research, this approach helps distinguish stable individual tendencies from chance variation, identify changes in decision-making or activity patterns, and evaluate whether observed behaviors reflect meaningful structure. Its results can support behavioral classification, model validation, and the study of how conditions or interventions alter variability over time.

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Research

JoVE Journal - Biology

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

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Cited by 8 •

2021

Direct stochastic optical reconstruction microscopy (dSTORM) is used to bypass the typical diffraction limit of light microscopy and to view exosomes at the nanometer scale. It can be employed in both two and three dimensions to characterize exosomes.

Research

JoVE Journal - Environment
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Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures

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Cited by 1 •

2021

Here, we present a protocol to investigate the impacts of hydraulic fracturing on nearby streams by analyzing their water and sediment microbial communities.

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro

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Cited by 5 •

2019

Galvanic vestibular stimulation in humans exhibits improvements in vestibular function. However, it is unknown how these effects occur. Here, we describe how to apply sinusoidal and stochastic electrical noise and evaluate appropriate stimulus amplitudes in individual medial vestibular nucleus neurons in the C57BL/6 mouse.

Reconstruction of Single-Cell Innate Fluorescence Signatures by Confocal Microscopy

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Cited by 1 •

2020

Here, a protocol is presented for optically extracting and cataloging innate cellular fluorescence signatures (i.e., cellular autofluorescence) from every individual live cell distributed in a three-dimensional space. This method is suitable for studying the innate fluorescence signature of diverse biological systems at a single-cell resolution, including cells from bacteria, fungi, yeasts, plants, and animals.

Imaging Intermediate Filaments and Microtubules with 2-dimensional Direct Stochastic Optical Reconstruction Microscopy

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Cited by 6 •

2018

The overall goal of this methodology is to give the optimal experimental conditions from sample preparation to image acquisition and reconstruction in order to perform 2D dual color dSTORM images of microtubules and intermediate filaments in fixed cells...

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