Biophysical Cues
Biophysical Cues - Related Videos
07:51
Spatial Cueing
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University Attention refers to the limited human ability to select some information for processing at the expense of other stimuli in the environment. Attention operates in all sensory modalities: vision, hearing, touch, even taste and smell. It is most often studied in the visual domain though. A common way to study visual attention is with a spatial cueing paradigm. This paradigm allows researchers to measure the consequences of focusing...
08:04
Measuring Sensitivity to Viewpoint Change with and without Stereoscopic Cues
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Cited by 1 •
2013
We discuss a novel method forviewpoint-rotation of visual stimuli, and demonstrate using a mirror stereoscopethe three-dimensional percept of rotation-in-depth. The technique can be used to investigate the role of stereoscopic cues in encoding viewpoint-rotated figures.
01:29
Non-Verbal Cues
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2025
Non-verbal communication extends beyond gestures and facial expressions to include vocal elements known as paralanguage. Paralanguage consists of non-verbal vocal cues such as pitch, loudness, speech rate, pauses, and non-verbal vocalizations like laughter, sighs, and moans. These elements not only accompany speech but also provide critical emotional and contextual information.The Role of Paralanguage in CommunicationParalanguage adds depth to spoken language by conveying emotions and...
11:43
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Cited by 7 •
2015
The mechanical properties and microstructure of the extracellular matrix strongly affect 3D migration of cells. An in vitro method to study the spatiotemporal cell migration behavior in biophysically variable environments, at both population and individual cell levels, is described.
07:51
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
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Cited by 6 •
2018
Cue reactivity is conceptualized as sensitivity to cues linked with drug-taking experiences that contribute to craving and relapse in abstinent humans. Cue reactivity is modeled in rats by measuring attentional orientation toward drug-associated cues that results in appetitive approach behavior in a cue reactivity test following self-administration and forced abstinence.
FAQs
Substrate stiffness provides mechanical information that cells detect through integrins and the cytoskeleton. These structures help convert physical forces at the cell-material interface into biochemical signals that can alter gene expression and cell fate. By tuning stiffness in engineered materials, researchers can investigate or guide changes in cell adhesion, differentiation, and tissue formation within controlled bioengineering systems.
Integrins, ion channels, and the cytoskeleton form linked sensing and force-transmission components. Integrins connect cells with their surroundings, ion channels respond to physical conditions, and the cytoskeleton helps transmit mechanical forces within the cell. Together, they convert environmental information into biochemical signaling, allowing external mechanics to influence gene expression and biological function.
Different cues describe different physical features of the cellular environment. Surface topography and matrix architecture provide structural organization, while mechanical strain and fluid shear stress apply changing forces; substrate stiffness alters the mechanical context of adhesion. Engineers can vary these parameters independently or together to study their effects on migration, differentiation, tissue organization, and formation.
Engineers recreate or tune physical conditions within biomaterials and tissue scaffolds by controlling properties such as stiffness, surface topography, matrix architecture, mechanical strain, or fluid shear stress. The selected design depends on the cellular behavior or tissue organization being studied. These platforms provide adjustable environments for examining how physical signals affect adhesion, migration, differentiation, and tissue formation.
Organ-on-chip platforms are useful when researchers need engineered environments that reproduce selected physical conditions around cells. They can incorporate factors such as fluid shear stress, mechanical strain, or matrix architecture to examine how cells respond to controlled surroundings. This makes them relevant for developing more physiologically relevant disease models and for studying biological function in bioengineering contexts.
Tuning biophysical cues can guide cell adhesion, migration, differentiation, tissue organization, and tissue formation. In bioengineering, these outcomes support the design of regenerative therapies, engineered tissues, and disease models that better reflect relevant physical environments. The approach also helps connect material or platform design with changes in gene expression and cell fate.