Bubble Dynamics

Bubble dynamics is the study of how gas-filled bubbles form, grow, deform, oscillate, and collapse within liquids or soft materials, and why these behaviors matter in fluid systems. Their motion is governed by pressure changes, surface tension, liquid viscosity, gas content, and interactions with nearby boundaries or bubbles; rapid collapse can generate intense local flows and stresses. In bioengineering, these principles help researchers design and control ultrasound-mediated drug delivery, contrast-enhanced imaging, sonoporation, and bubble-based microfluidic processes. Understanding bubble behavior improves treatment precision, limits unwanted tissue damage, and supports the development of safer biomedical devices and therapies.

Bubble Dynamics - Related Videos

Education

JoVE Core - Physics

Excess Pressure Inside a Drop and a Bubble

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2023

The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops. where γ corresponds to the surface tension. Recalling that the force per...

Research

JoVE Journal - Engineering

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

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Cited by 2 •

2021

A fast and reliable technique is proposed to control the shape oscillations of a single, trapped acoustic bubble that is based on coalescence technique between two bubbles. The steady-state, symmetry-controlled bubble shape oscillations allow analysis of the fluid flow generated in the vicinity of the bubble interface.

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Cited by 8 •

2017

A microfluidic chip was fabricated to produce pairs of gold dots for tandem bubble generation and fibronectin-coated islands for single-cell patterning nearby. The resultant flow field was characterized by particle image velocimetry and was employed to study various bioeffects, including cell membrane poration, membrane deformation, and intracellular calcium response.

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation

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Cited by 18 •

2012

Phase-shift nanoemulsions (PSNE) can be vaporized using high intensity focused ultrasound to enhance localized heating and improve thermal ablation in tumors. In this report, the preparation of stable PSNE with a narrow size distribution is described. Furthermore, the impact of vaporized PSNE on ultrasound-mediated ablation is demonstrated in tissue-mimicking phantoms.

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

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Cited by 12 •

2019

Here, we present a protocol for the formation of lipid bilayers using a contact bubble bilayer method. A water bubble is blown into an organic solvent, whereby a monolayer is formed at the water-oil interface. Two pipettes are manipulated to dock the bubbles to form a bilayer.

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