Cardiac Mechanics
Cardiac Mechanics - Related Videos
04:40
Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
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Cited by 55 •
2017
This protocol describes 3D bioprinting of cardiac tissue without the use of biomaterials. 3D bioprinted cardiac patches exhibit mechanical integration of component spheroids and are highly promising in cardiac tissue regeneration and as 3D models of heart disease.
11:51
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
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Cited by 16 •
2016
This manuscript describes the creation of defined engineered cardiac tissues using surface marker expression and cell sorting. The defined tissues can then be used in a multi-tissue bioreactor to investigate mechanisms of cardiac cell therapy in order to provide a functional, yet controlled, model system of the human heart.
01:28
Mechanism of Cardiac Arrhythmias
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2024
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
07:51
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
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Cited by 2 •
2023
Rapid myocardial and cardiac relaxation is essential for normal physiology. Mechanical relaxation mechanisms are now known to be dependent on strain rate. This protocol provides an overview of the acquisition and analysis of experiments to further study the mechanical control of relaxation.
08:25
Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
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Cited by 11 •
2015
Streptococcus pneumoniae forms discrete non-purulent microscopic lesions in the heart. Outlined is the protocol for a murine model of cardiac microlesion formation. Instruction is provided on microlesion visualization using microscopy, discrimination between early and late microlesions, and methods to detect cardiac remodeling in hearts of convalescent animals.
FAQs
Preload, afterload, wall stress, and tissue compliance jointly shape ventricular filling and ejection, but they describe different mechanical influences. Examining them together helps bioengineers relate chamber pressure to deformation and identify whether altered performance reflects loading conditions, wall mechanics, or reduced tissue compliance. This distinction is important when interpreting cardiac function quantitatively.
Electrical activation provides the timing that coordinates myocardial contraction. When activation and contraction are organized across the myocardium, force generation produces ventricular pressure during the cardiac cycle and supports blood flow. Cardiac mechanics therefore connects electrical events with measurable mechanical outcomes, allowing researchers to examine how activation relates to pressure, deformation, and ejection.
Remodeling, fibrosis, or injury can alter myocardial material properties and structural behavior. Those changes may modify how tissue deforms under load and how effectively contraction generates pressure, so mechanical measurements can reveal functional consequences over the cardiac cycle. This makes tissue mechanics relevant to assessing disease-related changes in cardiac performance and interpreting altered heart function.
A bioengineering assessment can pair imaging with pressure measurements, mechanical testing, and computational models. Imaging characterizes structure and deformation, pressure data captures chamber behavior, mechanical testing examines tissue responses, and models integrate these observations. Using several approaches supports a more complete interpretation of pressure, deformation, and blood flow during the cardiac cycle.
By relating structure and material properties to force, deformation, pressure, and flow, cardiac mechanics gives bioengineers performance targets for devices and materials used with the heart. The same framework can help evaluate whether a ventricular assist device, engineered heart tissue, or biomaterial supports mechanical demands associated with cardiac function and blood movement.
Mechanical measurements and computational models can show how remodeling, fibrosis, or injury changes cardiac performance, then provide outcomes for evaluating therapies. Researchers can examine pressure generation, deformation, and blood-flow-related behavior during the cardiac cycle to determine whether an intervention improves mechanical function. This approach links treatment assessment to measurable changes in heart performance.