Elastin-like Repeats
Elastin-like Repeats - Related Videos
08:54
Reliable Creation of a Murine Abdominal Aortic Aneurysm Model Using Elastin Sensitization and Perivascular Elastase
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2026
This protocol provides a repeatable and reliable method for inducing abdominal aortic aneurysms (AAAs) in C57BL/6 mice using elastin sensitization and perivascular elastase application, as an AAA model that incorporates an immune-sensitization component.
07:35
Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
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Cited by 48 •
2014
Elastin-like polypeptides are stimulus-responsive biopolymers with applications ranging from recombinant protein purification to drug delivery. This protocol describes the purification and characterization of elastin-like polypeptides and their peptide or protein fusions from Escherichia coli using their lower critical solution temperature phase transition behavior as a simple alternative to chromatography.
10:47
Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study
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Cited by 5 •
2011
The aim of this study was to mimic the native three layered architecture of the arterial wall. To accomplish this, electrospinning was employed with the use of a 3-1 (input-output) nozzle and blends of polycaprolactone, elastin, and collagen.
01:12
Elastin is Responsible for Tissue Elasticity
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2023
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column. Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
01:28
Infinitely Repeated Games
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2025
An infinitely repeated game is a scenario where players repeatedly engage in the same game without a predetermined end. This concept is crucial in understanding long-term interactions in various fields of the social sciences, including economics and international relations. Examples: Firms Setting Prices: Companies continuously adjust prices. Trade Negotiations: Countries consistently negotiate trade terms. Tit-for-Tat Strategy Cooperative Start: Players begin with a cooperative action,...
FAQs
Below their transition temperature, the sequences remain soluble, allowing an engineered material to stay dispersed. Above that threshold, they rapidly aggregate, producing a reversible change in molecular organization. This switch lets bioengineers couple temperature conditions to material assembly, mechanical behavior, or molecular release instead of relying on a permanently fixed state.
The X position provides a sequence-level design variable within the recurring pentapeptide. Altering it can support tunable behavior because the overall material response depends on sequence as well as temperature. In bioengineering, this modularity helps researchers design recombinant polypeptides and other materials whose properties or responsiveness can be adjusted for a particular use.
Genetic encoding makes the repeat sequence a programmable component of a recombinant polypeptide. Researchers can therefore incorporate the elastin-inspired motif into engineered biomaterials while preserving control over its sequence features. This approach supports systematic adjustment of elasticity, phase responsiveness, and molecular assembly across material designs rather than treating those properties as fixed.
A design can begin by selecting the repeat sequence and its variable residues, then incorporating the genetically encoded sequence into a chosen material format. The resulting construct can be used in recombinant polypeptides, hydrogels, coatings, or delivery systems. Temperature and sequence are the principal design variables highlighted for controlling assembly and material behavior.
Elastin-like Repeats can be incorporated into recombinant polypeptides, hydrogels, coatings, and drug-delivery systems. Each format provides a different context for using their tunable elasticity or responsive assembly. This range allows the same sequence-based design principle to support structural biomaterials, surface-related materials, and systems intended to regulate molecular release.
In a drug-delivery system, the reversible soluble-to-aggregated transition links temperature to molecular organization. That relationship can be used to influence when or how molecules are released, while sequence variation offers an additional design variable. The approach is therefore relevant when researchers want delivery behavior that responds to engineered material properties rather than remaining constant.
Their tunable elasticity and stimulus-responsive behavior provide design features for biomaterials used in tissue engineering and regenerative medicine. Incorporation into hydrogels or related engineered constructs can help connect material mechanics and assembly with the needs of a biological application. The same modular strategy also supports therapeutic delivery, extending its relevance beyond structural scaffolds.