Electromechanical Mapping
Electromechanical Mapping - Related Videos
11:08
Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
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2025
Here, we present a protocol to fabricate a unique two-layer microfluidic device to study the electromechanical regulation of epithelial tissue homeostasis. The device applies static physiological electric currents perpendicular to the tissue plane, impacting cell-cell adhesion, proliferation, and extrusion. Live-cell imaging and mechanical stress measurements reveal mechanisms of these processes.
07:15
A Novel Method for In Situ Electromechanical Characterization of Nanoscale Specimens
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Cited by 2 •
2017
Isolating electrical and thermal effects on electrically assisted deformation (EAD) is very difficult using macroscopic samples. Metallic sample micro- and nanostructures together with a custom test procedure have been developed to evaluate the impact of applied current on the formation without joule heating and evolution of dislocations on these samples.
12:52
Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity
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Cited by 7 •
2020
We present a protocol for evaluating the electromechanical effects of GtACR1 activation in rabbit cardiomyocytes. We provide detailed information on cell isolation, culturing and adenoviral transduction, and on functional experiments with the patch-clamp and carbon-fiber techniques.
06:58
Fate Mapping
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2023
Fate mapping is a technique used to understand how embryonic cells divide, differentiate, and migrate during development. In classic fate mapping experiments, cells in different areas of an embryo are labeled with a chemical dye and then tracked to determine which tissues or structures they form. Technological improvements now allow for individual cells to be marked and traced throughout embryonic development and adulthood. This video reviews the concepts behind fate mapping, and then details a...
11:03
Motor Maps
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California One principle of brain organization is the topographic mapping of information. Especially in sensory and motor cortices, adjacent regions of the brain tend to represent information from adjacent parts of the body, resulting in maps of the body expressed on the surface of the brain. The primary sensory and motor maps in the brain surround a prominent sulcus known as the central sulcus. The cortex...
FAQs
The central analytical step is aligning electrical and mechanical measurements in both space and time. This pairing lets investigators examine whether regions that show electrical activity also exhibit corresponding motion or force, rather than interpreting either signal alone. The resulting relationship provides a functional assessment of electromechanical coupling within the tissue being studied.
Electrophysiological recordings describe the tissue’s electrical activity, while imaging, displacement tracking, or force measurements capture its mechanical response. Using these complementary readouts allows a study to connect the initiating signal with movement or force generation. The selected mechanical measurement can therefore be adapted to the tissue, engineered construct, or experimental question.
Electromechanical mapping can identify changes in activation or contraction by examining their spatial and temporal relationship. Abnormal patterns become visible when electrical and mechanical data are evaluated together. This combined view supports characterization of tissue function and helps investigate situations in which signaling and movement do not follow the expected relationship.
Electromechanical coupling provides a functional criterion for judging whether an engineered tissue behaves coherently across electrical and mechanical domains. Measurements can show how activity relates to contraction or force in the construct, adding information beyond structure alone. This supports assessment of engineered tissues intended to reproduce or improve biological function.
A typical workflow records electrical activity while collecting a mechanical readout through imaging, displacement tracking, or force measurement. Investigators then align the datasets spatially and temporally, compare the electrical and mechanical patterns, and evaluate their coupling. This sequence converts separate signals into an integrated view of tissue activation and mechanical behavior.
The electrical channel generally comes from electrophysiological recording, whereas the mechanical channel may come from imaging, displacement tracking, or force measurement. These options provide different ways to describe motion or force while preserving the central comparison with electrical activity. The combination selected depends on the tissue or construct and the intended functional assessment.
Researchers can use the method when disease models or drug-testing studies require functional information about both activation and contraction. By comparing electrical and mechanical behavior, investigators can characterize abnormal patterns and evaluate tissue performance. The resulting measurements help connect experimental interventions with changes in electromechanical function rather than considering electrical or mechanical data independently.
In bioengineering, the measurements provide functional evidence for designing therapies and biomaterials that improve tissue performance. Mapping can show whether an engineered construct or treated tissue develops coordinated electrical and mechanical behavior. That information complements disease modeling and drug testing by linking design choices with the tissue’s observed activation, motion, or force patterns.