Fluid Shear Flow
Fluid Shear Flow - Related Videos
09:20
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
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Cited by 10 •
2016
Different levels and patterns of fluid shear are known to modulate endothelial gene expression, phenotype and susceptibility to disease. We discuss the assembly and use of 'shear rings': a model that produces unidirectional, periodic shear stress patterns. Shear rings are simple to assemble, economical and can produce high cell yields.
12:43
Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress
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Cited by 51 •
2012
We are describing a method to subject adherent cells to laminar flow shear stress in a sterile continuous flow circuit. The cells' adhesion, morphology can be studied through the transparent chamber, samples obtained from the circuit for metabolite analysis and cells harvested after shear exposure for future experiments or culture.
10:28
Experimental Measurement of Settling Velocity of Spherical Particles in Unconfined and Confined Surfactant-based Shear Thinning Viscoelastic Fluids
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Cited by 15 •
2014
This paper demonstrates the experimental procedure to measure terminal settling velocities of spherical particles in surfactant-based shear thinning viscoelastic fluids. Fluids over a wide range of rheological properties are prepared and settling velocities are measured for a range of particle sizes in unbounded fluids and fluids between parallel walls.
01:27
Steady Flow of a Fluid Stream
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2024
Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2. During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
12:39
Computational Fluid Dynamics Simulations of Blood Flow in a Cerebral Aneurysm
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2023
Source: Joseph C. Muskat, Vitaliy L. Rayz, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana The objective of this video is to describe recent advancements of computational fluid dynamic (CFD) simulations based on patient- or animal-specific vasculature. Here, subject-based vessel segmentations were created, and, using a combination of open-source and commercial tools, a high-resolution numerical solution was determined within a flow model.
FAQs
Shear stress increases when neighboring fluid layers have a greater difference in velocity across a given distance. Viscosity determines how strongly the fluid resists this relative motion, so the same velocity gradient can produce different forces in different fluids. This relationship helps researchers set conditions that reproduce desired mechanical environments in bioengineering systems.
Flow rate, fluid viscosity, and channel geometry are central variables because they shape the velocity gradients and resulting forces at surfaces or interfaces. Changing any of them can alter the mechanical environment experienced by cells or engineered materials. Controlling these parameters allows researchers to compare experiments consistently and tune conditions for specific biological or device-related goals.
Shear stress acts parallel to a surface or interface, exposing attached cells to directional mechanical forces rather than only normal pressure. In bioengineering studies, those forces can influence cell adhesion, alignment, growth, and differentiation. Recognizing this directional effect is important when evaluating how cells respond to flow-based environments or when designing systems intended to guide tissue organization.
A practical workflow begins by specifying the fluid, flow rate, and channel or chamber geometry, then assessing the resulting velocity gradients and shear stress. Researchers can use that characterization to determine whether the system represents the intended mechanical environment. Establishing these conditions before biological testing improves interpretation of cell or tissue responses.
It is useful when a microfluidic system must expose cells, materials, or interfaces to controlled mechanical forces. By relating flow rate, viscosity, and channel geometry to shear conditions, designers can adjust the environment within the device. This supports systems that model aspects of blood circulation, investigate cell responses, or evaluate biomedical device performance.
In blood-circulation models, controlled shear conditions help reproduce a mechanically relevant flow environment. In bioreactors, the same principle enables researchers to regulate forces experienced by cells or engineered tissues. Measurements of shear stress can then support evaluation of tissue behavior and refinement of cell-based systems, including conditions related to adhesion, growth, alignment, and differentiation.