Fluid Structure Interaction
Fluid Structure Interaction - Related Videos
13:43
Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
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Cited by 15 •
2013
We describe a correlative microscopy method that combines high-speed 3D live-cell fluorescent light microscopy and high-resolution cryo-electron tomography. We demonstrate the capability of the correlative method by imaging dynamic, small HIV-1 particles interacting with host HeLa cells.
13:07
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Cited by 4 •
2022
There is a need to determine which atherosclerotic lesions will progress in the coronary vasculature to guide intervention before myocardial infarction occurs. This article outlines the biomechanical modeling of arteries from Optical Coherence Tomography using fluid-structure interaction techniques in a commercial finite element solver to help predict this progression.
11:14
Mass Spectrometric Approaches to Study Protein Structure and Interactions in Lyophilized Powders
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Cited by 19 •
2015
Here, we present detailed protocols for solid-state amide hydrogen/deuterium exchange mass spectrometry (ssHDX-MS) and solid-state photolytic labeling mass spectrometry (ssPL-MS) for proteins in solid powders. The methods provide high-resolution information on protein conformation and interactions in the amorphous solid-state, which may be useful in formulation design.
06:43
Fluid Aspiration from Mouse Glomeruli: A Method to Aspirate Glomerular Fluid from Mouse Using Two-Photon Mediated Micropuncture
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2023
This video showcases fluid aspiration from mouse glomeruli using the two-photon mediated micropuncture technique. The technique provides access to the living mouse’s glomeruli and thus helps gain insights into renal physiology.
01:10
Antibody Structure
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2019
Overview Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding. The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains Antibodies consist of four polypeptide chains: two identical heavy...
FAQs
Changes in fluid pressure, velocity, and shear stress can produce different structural responses, so researchers examine them together rather than treating any one force as sufficient. Pressure and velocity changes affect loading, while shear stress describes frictional force along surfaces. Tracking these variables helps relate physiological flow conditions to deformation in vessels, valves, and implants.
The interaction is bidirectional: fluid forces can deform a biological tissue or device, and that deformation can redirect fluid and redistribute forces. This feedback means that a fixed-shape analysis may not represent the actual mechanical environment. Accounting for both sides helps explain how altered vessel geometry or device motion changes local flow behavior.
Mathematical models provide a framework for representing the interaction, computational simulations allow researchers to examine predicted flow and structural responses, and experimental measurements provide observations for evaluating those predictions. Using these approaches together supports a more complete analysis of physiological forces and deformation than relying on a single source of information.
A typical analysis identifies the biological structure or medical device, represents the relevant fluid and solid behavior with a mathematical model, examines the coupled response through computational simulation, and compares or complements the results with experimental measurements. This workflow connects physiological loading to structural deformation and changes in fluid distribution.
Bioengineering applications include blood flow through compliant vessels, heart valves, and vascular implants. These systems are useful because their performance depends on both fluid movement and the mechanical response of tissue or device components. Studying them can reveal how physiological forces influence function and can guide evaluation of designs intended for medical use.
By linking fluid forces with deformation, these studies help explain disease-related changes in biological structures and assess how medical devices perform under physiological conditions. The resulting analyses can inform improvements in device design and support safer, more accurate approaches to diagnosis and treatment, particularly for systems exposed to changing blood-flow forces.