World To Chip Connections
World To Chip Connections - Related Videos
11:23
Lensless Fluorescent Microscopy on a Chip
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Cited by 8 •
2011
A lensless on-chip fluorescent microscopy platform is demonstrated that can image fluorescent objects over an ultra-wide field-of-view of e.g., >0.6-8 cm2 with <4μm resolution using a compressive sampling based decoding algorithm. Such a compact and wide-field fluorescent on-chip imaging modality could be valuable for high-throughput cytometry, rare-cell research and microarray-analysis.
07:50
Chip-Based Digital PCR to Detect Rare Transcript Variants Using a Nanofluidic Chip
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2025
This video demonstrates chip-based digital PCR — a variation of the digital PCR technique that is useful in detecting rare transcript variants. The PCR reaction is partitioned into the chambers of a nanofluidic chip, each of which acts as an independent reaction. The detection of fluorescence signals from the chambers with amplified targets confirms the presence of rare transcript variants in the sample.
01:35
Organ-on-Chip Models
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2026
Introduction to Organ-on-Chip Models Organ-on-chip models are advanced microphysiological systems that recreate key structural and functional features of human organs in a controlled laboratory setting. These devices integrate living human cells within microfluidic channels, allowing researchers to simulate tissue–tissue interfaces, fluid flow, and mechanical forces that are essential for normal organ function. Unlike traditional cell cultures, which often lack these dynamic physiological cues,...
11:16
A Microfluidic Chip for ICPMS Sample Introduction
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Cited by 4 •
2015
We present a discrete droplet sample introduction system for inductively coupled plasma mass spectrometry (ICPMS). It is based on a cheap and disposable microfluidic chip that generates highly monodisperse droplets in a size range of 40−60 µm at frequencies from 90 to 7,000 Hz.
12:43
On-Chip Endothelial Inflammatory Phenotyping
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Cited by 3 •
2012
Microfluidic flow chambers etched by photolithography and fabricated from PDMS are applied to probe functional outcomes associated with EC dysfunction and inflammation. In a representative experiment, the ability of differential shear stress to modulate monocytic cell adhesion to cytokine activated EC monolayers is demonstrated.
FAQs
Transport is controlled by combining defined entry and exit points with either pumping or pressure-driven movement. Inlets and outlets establish where material enters and leaves, while tubing or membranes provide the physical link to the microscale device. Sensors can then track flow, concentration, or electrical response, helping investigators relate interface conditions to chip measurements.
Pump-driven transport uses a device to regulate movement through the connection, whereas a pressure gradient moves material because of a controlled pressure difference. Both approaches can guide external fluids through the chip, but the selected strategy determines how transport is established and managed during an experiment. The overview does not specify that one approach is universally superior.
Sensors add measurements to the physical connection between an external input and the chip environment. They can monitor flow, concentration, or electrical response while the experiment proceeds, providing information about conditions inside or associated with the system. These readings help investigators interpret microscale results and assess whether the connected biological environment is behaving as intended.
Reliable coupling makes the transfer from a complex real-world input to a controlled microscale environment more consistent. This matters because differences at the interface can affect what reaches the chip and how measurements are interpreted. More dependable connections therefore support reproducible automated assays, drug-testing studies, disease models, and monitoring applications.
A typical workflow begins by connecting the external sample or fluid to an inlet, routing it through tubing or across a membrane, and providing an outlet for continued transport. Researchers then establish movement with a pump or pressure gradient and monitor relevant flow, concentration, or electrical signals. This sequence links sample delivery with controlled measurement.
They are useful when experiments require continuous sampling, automated assays, drug testing, disease modeling, or environmental and diagnostic monitoring. The interface allows external material or signals to interact with a controlled chip system without treating the chip as an isolated device. This supports workflows that connect ongoing biological or environmental inputs with microscale measurements.
In bioengineering, the connections provide a practical bridge between real-world biological inputs and organ-on-chip or microfluidic environments. Controlled delivery and monitored responses can support drug-testing experiments and disease models, while continuous sampling can extend measurements over time. The resulting data may help relate microscale behavior to broader biological and clinical insights.