Asymmetric Division
Asymmetric Division - Related Videos
08:19
Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
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Cited by 4 •
2016
Here, we present a protocol to quantify precise stepping in rodents. Cortical and the spinal central pattern generator signals are required for precise foot-placement during obstructed locomotion. We report here the novel constrained walking task that directly examines precise stepping behavior.
05:44
Cell Division - Concepts
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2019
Cell division is fundamental to all living organisms and required for growth and development. As an essential means of reproduction for all living things, cell division allows organisms to transfer their genetic material to their offspring. For a unicellular organism, cellular division generates a completely new organism. For multicellular organisms, cellular division produces new cells for the general development of the organism, as well as produces healthy cells to replace damaged cells from...
06:20
Cell Division - Student Protocol
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2019
Observing the Cell Cycle in a Root Tip ExpandHypotheses: The experimental hypothesis is that in root tips slices that have been treated with nocodazole, a chemical that interferes with microtubular polymerization, all of the cells will be arrested at the same stage of the cell cycle and that in untreated onion tip slices all of the different stages of the cell cycle will be visualized. The null hypothesis is that there will be no differences in mitosis between the two groups and that different...
10:03
An Introduction to Cell Division
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2023
Cell division is the process by which a parent cell divides and gives rise to two or more daughter cells. It is a means of reproduction for single-cell organisms. In multicellular organisms, cell division contributes to growth, development, repair, and the generation of reproductive cells (sperms and eggs). Cell division is a tightly regulated process, and aberrant cell division can cause diseases, notably cancer. JoVE's Introduction to Cell Division will cover a brief history of the landmark...
09:06
Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors
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Cited by 5 •
2023
This work develops an antibody uptake assay for imaging intra-lineage Notch/DeltaD signaling in dividing radial glia progenitors of the embryonic zebrafish brain.
FAQs
Three linked events are central: the cell establishes polarity, the mitotic spindle is positioned relative to that polarity, and cytokinesis separates cellular contents unequally. Their coordination determines whether daughter cells receive different molecular components or developmental instructions. Disruption at any stage can alter the balance between specialized-cell production and maintenance of renewing cell populations.
Mitotic spindle positioning determines the plane in which the parent cell separates. In an asymmetric division, that orientation helps distribute cellular contents and fate determinants unequally between the two emerging daughter cells. Consequently, spindle placement connects the cell’s polarity system to the distinct developmental fates that daughter cells may adopt.
Fate determinants are molecular components whose unequal inheritance can direct daughter cells toward different developmental outcomes. When cytokinesis partitions these determinants unevenly, the resulting cells can receive different instructions even though they originate from the same parent. This mechanism helps generate specialized cells while preserving populations capable of continued renewal.
During embryonic development, asymmetric division helps produce cells with different developmental fates, expanding cellular diversity from initially related populations. The same principle contributes to tissue organization by placing specialized cells and renewing populations in appropriate relationships. These outcomes allow developing tissues to become structured rather than simply increasing cell number.
Asymmetric division helps balance two needs within a stem cell population: producing a daughter cell that can enter a specialized developmental pathway while retaining a renewing population. This balance is important for tissue maintenance and repair because it supports replacement or organization of cells without exhausting the source of continued renewal.
Researchers examine asymmetric division because its regulation connects cell-fate decisions with tissue maintenance, organization, and repair. In regenerative research, the process provides context for understanding how renewing and specialized populations arise. In disease studies, defects in its regulation are relevant because they can disturb cell fates and contribute to abnormal growth.