Av Groove Implantation
Av Groove Implantation - Related Videos
07:59
Implantation of Engineered Tissue in the Rat Heart
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Cited by 4 •
2009
Here, we describe a cardiac surgical procedure to implant engineered tissue in the atrioventricular (AV)-groove of an adult Lewis rat.
13:50
A Microfluidic Device with Groove Patterns for Studying Cellular Behavior
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Cited by 2 •
2007
We describe a protocol for the fabrication of microfluidic devices that can enable cell capture and culture. In this approach patterned microstructures such as grooves within microfluidic channels are used to create low shear stress regions within which cell can dock.
08:53
The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
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Cited by 38 •
2016
We describe a microsurgical approach for the generation of an arteriovenous (AV) loop as a model for analyzing vascularization in vivo in an isolated and well-characterized environment. This model is not only useful for the investigation of angiogenesis, but is also optimally suited for engineering axially vascularized and transplantable tissues.
03:58
Implantation of Cranial Imaging Window in Mouse Model: A Surgical Procedure to Implant Glass-based Coverslip for Stable Optical Access to Regions of Murine Brain
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2023
This video presents a surgical procedure to implant cranial window in a mouse model for stable optical access to different regions of the brain.
03:12
In Vivo Analysis of Implant-Associated Bacterial Infections Using Zebrafish Embryos
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2025
Source: Zhang, X. et. al., A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection. J. Vis. Exp. (2019)This video demonstrates a zebrafish embryo model for studying infections linked to implanted biomaterials. Injecting Staphylococcus aureus with polystyrene microspheres enhances bacterial survival, confirming the infection-promoting role of implanted materials.
FAQs
Precise localization allows investigators to place an implant near selected cardiac tissues while preserving the anatomical relationship between atrial and ventricular regions. This matters because local positioning makes it possible to examine signaling and tissue interactions at a defined site, rather than treating the heart as a uniform environment.
Controlled insertion is important because the approach is designed to limit disruption of surrounding myocardium, valves, and coronary vessels. By controlling where and how material enters the AV groove, researchers can help preserve nearby cardiac structures while creating a consistent location for observing local effects, tissue responses, and functional recovery.
The resulting observations can include local signaling, cell integration, structural remodeling, and functional recovery. These readouts connect the implanted material or device with both tissue-level and functional changes at the cardiac site. In developmental studies, the localized approach can also help relate implantation-site responses to heart development and electrical conduction.
A basic workflow starts with precise localization of the atrioventricular groove, followed by controlled insertion of the selected cells, tissue, biomaterial, or experimental device. Subsequent observations focus on nearby cardiac tissues and outcomes such as integration, remodeling, signaling, or recovery. Keeping these stages anatomically focused helps connect the intervention with local responses.
AV groove implantation can accommodate cells, tissue, biomaterials, and experimental devices. This range allows the same anatomical strategy to support different biological questions, from examining how living cells integrate with cardiac tissue to evaluating how a material or device interacts with the local environment. The shared feature is placement at a defined cardiac site.
It is useful when a study requires a defined cardiac location for testing tissue interactions or therapeutic strategies. In heart-development research, it can help investigate anatomical and signaling relationships; in conduction studies, it provides access to a site near relevant cardiac regions; and in regeneration research, it supports evaluation of integration, remodeling, and functional recovery.