Biological Systems
Biological Systems - Related Videos
13:19
The Use of Chemostats in Microbial Systems Biology
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Cited by 67 •
2013
Cell growth rate is a regulated process and a primary determinant of cell physiology. Continuous culturing using chemostats enables extrinsic control of cell growth rate by nutrient limitation facilitating the study of molecular networks that control cell growth and how those networks evolve to optimize cell growth.
10:38
Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
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Cited by 2 •
2010
We present principles of oxygen measurements by phosphorescence quenching and review design of porphyrin-based dendritic nanosensors for oxygen imaging in biological systems.
08:17
Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
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Cited by 24 •
2011
Fluorescent nanoparticles produced in our lab are used for imaging ion concentrations and ion fluxes in biological systems such as cells during signaling and interstitial fluid during physiological homeostasis.
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Cited by 5 •
2016
Integration of data from genome-wide sequencing experiments and metabolomics experiments is a challenge. In this paper we report, for the first time, generation, analysis and integration of transcriptome, cistrome and metabolome data from breast cancer cells treated with estradiol.
07:49
Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO
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Cited by 60 •
2014
To obtain high-resolution images of fluorescently labeled cells within large tissues, ideally, the biological samples should be imaged without sectioning. 3DISCO is a straightforward tissue clearing procedure based on sequential incubation with organic solvents. Upon clearing, the organs become transparent allowing an end-to-end laser scan of the specimen.
FAQs
Feedback control helps biological systems keep internal conditions within workable ranges as environments change. A system adjusts activity through coordinated responses rather than relying on a one-time action. This principle connects molecular and cellular regulation with organism-level stability, while disruptions in control can help explain how altered regulation contributes to disease.
Chemical signaling and gene regulation coordinate activity across biological levels, allowing information to influence cellular or organismal behavior. Because these processes interact rather than operate independently, their combined effects can produce system-level behavior that is not apparent from a single component. Studying both helps explain development, adaptation, and disease within a shared biological framework.
Energy transformation links resource use to biological activity across levels. When this flow changes or becomes poorly coordinated, the effects can extend beyond one component and alter network behavior. Considering energy alongside signaling and gene regulation helps researchers connect cellular processes with broader biological outcomes, including changes in organisms and ecosystems.
A systems-level view shows how a change in one component can affect an entire network, whereas a component-focused view may emphasize that element without capturing its relationships. This distinction matters because outcomes emerge from interactions among molecules, cells, organisms, and ecosystems. It supports more complete explanations of development, disease, adaptation, and ecosystem function.
Tracing relationships across molecules, cells, organisms, and ecosystems helps researchers connect local processes with larger outcomes. They can examine how chemical signaling, gene regulation, energy transformation, and feedback control contribute to coordinated behavior, then interpret effects when one part changes. This approach links underlying mechanisms to development, adaptation, disease, and ecosystem function.
Applications are especially relevant when a biological outcome depends on many connected processes. In biomedical research and drug development, systems-level analysis can clarify how changes propagate through a network. Synthetic biology and conservation also benefit from this perspective because it relates coordinated biological activity to broader network behavior and ecosystem function.
These approaches connect changes in individual components with responses at larger levels of organization. Examining regulation, signaling, energy transformation, and feedback together can help researchers relate biological activity to adaptation in organisms and coordinated behavior in ecosystems. The same perspective supports conservation by showing why effects in one part of an ecological network may extend across the system.