Bronchioles
Bronchioles - Related Videos
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Cited by 20 •
2012
Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.
06:57
The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
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Cited by 11 •
2017
The mucus plugged airways of cystic fibrosis (CF) patients are an ideal environment for microbial pathogens to thrive. The manuscript describes a novel method for studying the CF lung microbiome in an environment that mimics where they cause disease and how alterations of chemical conditions can drive microbial dynamics.
04:35
Ex vivo Pig Lung Model of Biofilm: A Technique to Develop Lung Model to Study Bacterial Biofilms on Pig Bronchiolar Tissue
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2025
This video describes the protocol for developing an ex vivo pig lung model of bacterial biofilm on infected bronchiolar tissue. Biofilms are bacterial aggregates embedded in a matrix adherent to a surface. This model is used to study the antibiotic susceptibility of bacteria at different stages of biofilm formation.
03:03
Pig Bronchiolar Tissue Extraction: A Procedure to Dissect Bronchiolar Tissue Sections From Porcine Lungs
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2025
In this video, we describe a surgical procedure to extract bronchiolar tissues from harvested pig lung. The ex vivo bronchiolar tissue could be used to develop infection models for studying chronic lung infections.
05:33
Physiology of the Circulatory System - Concepts
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2019
Homeostasis Conditions in the external environment of an organism can change rapidly and drastically. To survive, organisms must maintain a fairly constant internal environment, which involves continuous regulation of temperature, pH, and other factors. This balanced state is known as homeostasis, which describes the processes by which organisms maintain their optimal internal conditions. To maintain homeostasis, organisms have developed structures with distinct functions. Physiology is the...
FAQs
Smooth muscle controls bronchiolar caliber by changing the diameter of the airway. When it constricts, the passage narrows and airflow resistance rises; when it relaxes, the passage widens and air can move more readily. This adjustable control is important because bronchioles lack the cartilage found in larger bronchi and therefore rely on muscular regulation.
Without cartilage, bronchioles do not have the same rigid structural support as larger bronchi. Their walls instead depend strongly on smooth-muscle activity to regulate airway diameter. This arrangement makes constriction and dilation especially important for interpreting changes in airflow resistance and for understanding how small airway passages influence lung function.
Bronchioles link the conducting airway network with alveolar regions. Terminal bronchioles conduct air, while respiratory bronchioles lead toward areas where oxygen and carbon dioxide exchange occurs. This arrangement allows biologists to study how regulated airway passages guide air toward exchange surfaces and how airway organization contributes to the integrated function of the lungs.
Examining bronchioles helps researchers relate small-scale airway behavior to larger respiratory outcomes. Their diameter regulation provides a way to investigate airflow resistance, while their position within the branching lung network connects air transport with alveolar exchange. These relationships make bronchioles useful for explaining how airway structure and control contribute to efficient breathing.
Bronchioles are relevant to these research areas because their smooth-muscle regulation and role in airflow directly connect them with airway function. Studying bronchioles can help investigators examine how changes in airway behavior relate to resistance and lung performance. This provides biological context for research into asthma, chronic obstructive pulmonary disease, and airway inflammation.
Bronchioles are relevant to inhaled-therapy research because they form part of the branching airway network through which air moves into the lungs. Their smooth-muscle-controlled diameter and location before alveolar regions provide context for considering airway function and delivery. Research can therefore connect treatment approaches with the anatomy and regulation of respiratory passages.