Cardiac Physiology Study
Cardiac Physiology Study - Related Videos
01:18
Physiology of the Heart: The Cardiac Cycle
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2025
The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves. Diastole: The Relaxation Phase During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
08:16
Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
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Cited by 3 •
2016
In these studies, we provide methodology for novel, neonatal, murine cardiac scaffolds for use in regenerative studies.
14:26
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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Cited by 16 •
2014
Two exercise paradigms were tested on a newly developed chemically induced menopausal mouse model to examine the impact of menopause on exercise capacity and cardiac adaption to exercise.
11:51
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
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Cited by 16 •
2016
This manuscript describes the creation of defined engineered cardiac tissues using surface marker expression and cell sorting. The defined tissues can then be used in a multi-tissue bioreactor to investigate mechanisms of cardiac cell therapy in order to provide a functional, yet controlled, model system of the human heart.
11:55
Physiological Correlates of Emotion Recognition
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California The autonomic nervous system (ANS) controls the activity of the body's internal organs and regulates changes in their activity depending on the current environment. The vagus nerve, which innervates many of the internal organs, is an important part of the system. When our brain senses danger, vagal tone is inhibited, leading to a set of changes in the body designed to make us more prepared to fight or...
FAQs
Pacemaker cells initiate electrical impulses that travel through the heart’s conduction system in an organized sequence. This timing allows cardiac muscle to contract in coordination with changing chamber pressures rather than contracting randomly. Studying this sequence helps explain how electrical activity is translated into effective movement of blood through the circulation.
Calcium provides the link between electrical activation and contraction of cardiac muscle. When impulses reach the muscle, calcium-dependent processes enable the chambers to generate force and alter pressure during the cardiac cycle. Examining this relationship is important for understanding how changes in electrical activity can influence mechanical performance.
Heart rate and stroke volume together describe how much blood the heart moves over time, while vascular resistance influences how readily blood flows through the circulation. Considering these variables together gives a broader view of tissue oxygen delivery than examining any one measurement alone, especially when cardiovascular conditions or demands change.
A study of exercise responses can organize observations around changes in heart rate, stroke volume, cardiac output, and vascular resistance. These measures can then be considered alongside electrical activity, contraction, and blood flow to evaluate how cardiovascular function adjusts to increased physiological demand and how effectively tissues receive oxygen.
Cardiac physiology provides a framework for connecting abnormal electrical activity, impaired muscle contraction, altered chamber pressure, or disrupted blood flow with broader cardiovascular dysfunction. Comparing these linked processes can help researchers and students examine disease mechanisms in biological context, rather than treating heart rhythm, pumping performance, and tissue oxygen delivery as isolated topics.
Researchers can use cardiac physiology to assess whether an intervention changes electrical activity, calcium-dependent contraction, heart rate, stroke volume, cardiac output, or vascular resistance. Relating these responses to blood flow and tissue oxygen delivery helps clarify the intervention’s effects on integrated cardiovascular function and supports interpretation of both beneficial and disruptive outcomes.