Cell Volume Increase

Cell volume increase is the enlargement of a cell as it accumulates water, ions, and cellular material, a fundamental feature of growth, development, and tissue maintenance. It can result from biosynthesis of proteins, lipids, and organelles, or from osmotic water influx when intracellular solute concentration rises; transporters and ion channels help regulate this change and preserve membrane integrity. Studying cell volume increase helps researchers distinguish normal growth from pathological swelling caused by injury or disrupted ion balance, while informing research on cell proliferation, differentiation, cancer biology, and responses to environmental stress.

Cell Volume Increase - Related Videos

Education

JoVE Core - Math Fundamentals

Increasing Function

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2025

An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The average...

Research

JoVE EoE - Pancreatic Cancer

Ex Vivo T Cell Stimulation in the Pancreatic Tumor: A Method to Increase Cytokine Production in T Cells

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2023

This article describes the technique for ex vivo T cell stimulation to increase the intracellular concentration of cytokines such as interferon-gamma or IFN-gamma and tumor necrosis factor-alpha or TNF-alpha in the T cell. These cytokines mediate an effective anti-tumor response and can have a therapeutic role in the...

Increased Body Temperature

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2024

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

Increased pulse rate

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2024

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues. Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...

Increased Intracranial Pressure l: Introduction

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2026

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

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