Dehydration Synthesis

Dehydration synthesis is a chemical reaction that joins smaller molecules to form a larger molecule while removing a molecule of water, making it fundamental to biological organization. During the reaction, a hydroxyl group from one molecule and a hydrogen atom from another combine to release water as a new covalent bond forms between the remaining components. Cells use this process to assemble carbohydrates from monosaccharides, proteins from amino acids, and nucleic acids from nucleotides. Dehydration synthesis supports the construction of cellular structures and biological macromolecules, while its reverse process, hydrolysis, breaks these bonds by adding water during digestion and metabolism.

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JoVE Core - Biology

Dehydration Synthesis

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2026

Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

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2023

Overview Ethers can be prepared from organic compounds by various methods. Some of them are discussed below, Preparation of Ethers by Alcohol Dehydration In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K. This method is a nucleophilic substitution reaction. The two alcohol molecules...

Acid-Catalyzed Dehydration of Alcohols to Alkenes

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2025

In a dehydration reaction, a hydroxyl group in an alcohol is eliminated along with the hydrogen from an adjacent carbon. Here, the products are an alkene and a molecule of water. Dehydration of alcohols is generally achieved by heating in the presence of an acid catalyst. While the dehydration of primary alcohols requires high temperatures and acid concentrations, secondary and tertiary alcohols can lose a water molecule under relatively mild conditions. The acid-catalyzed dehydration of...

Dehydration of Aldols to Enals: Base-Catalyzed Aldol Condensation

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2025

This lesson delves into the aldol condensation catalyzed by bases, where aldols undergo dehydration to enals. As shown in Figure 1, the β-hydroxy aldehyde formed in a base-catalyzed aldol addition reaction dehydrates on heating to yield an unsaturated carbonyl product, which is commonly referred to as an enal. Figure 1. The dehydration of a β-hydroxy aldehyde to an enal. This process follows a two-step mechanism, as depicted in Figure 2. Here, the base first deprotonates the mildly acidic...

Hydrogel Synthesis

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2023

Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...

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