Adhesive Forces
Adhesive Forces - Related Videos
09:48
Investigating Single Molecule Adhesion by Atomic Force Spectroscopy
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Cited by 5 •
2015
A protocol to couple a large variety of single molecules covalently onto an AFM tip is presented. Procedures and examples to determine the adhesion force and free energy of these molecules on solid supports and bio-interfaces are provided.
01:14
Adhesion
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2019
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules. Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
06:44
Creation of Abdominal Adhesions in Mice
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Cited by 9 •
2016
Abdominal adhesions that form after surgery are a major cause of pain, infertility, and hospitalization and reoperation for small bowel obstruction. Our surgical procedure for creating abdominal adhesions in mice is a reliable tool to study the mechanisms underlying the formation of adhesions.
06:45
Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope
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Cited by 4 •
2019
We describe the detailed procedures and strategies to measure the mechanical properties and mechanical unfolding pathways of single protein molecules using an atomic force microscope. We also show representative results as a reference for selection and justification of good single protein molecule recordings.
12:26
Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Cited by 2 •
2022
Near-UV lithography and traction force microscopy are combined to measure cellular forces on micropatterned hydrogels. The targeted light-induced release of single cells enables a high number of measurements on the same sample.
FAQs
Hydrogen bonding, electrostatic attraction, and van der Waals forces can all contribute to adhesion at biological interfaces. Their relative influence depends on the chemical groups present on the interacting surfaces and on the surrounding environment. This molecular balance helps determine whether water, cells, tissues, or biological coatings attach effectively and remain associated under particular conditions.
Surface chemistry determines which intermolecular interactions can form, while contact area affects how many interactions occur across an interface. A surface with compatible chemical properties and greater effective contact can therefore support stronger attachment or spreading. These factors help explain why biological materials interact differently with extracellular matrix proteins, mucus, plant tissues, or engineered coatings.
Environmental conditions can alter how surfaces interact by influencing the molecular contacts available at an interface. Because adhesive effects depend partly on the surrounding environment, the same biological material may attach, spread, or move differently under different conditions. Accounting for this dependence is important when interpreting transport, tissue organization, or cell-surface interaction studies.
Within plant xylem, adhesion helps water interact with the surfaces of the conducting tissue as it moves through the plant. This surface association contributes to the behavior of water during transport, alongside the geometry and chemistry of the xylem interface. Studying this role connects molecular surface interactions with the larger biological process of plant water movement.
Adhesion enables cells to attach to extracellular matrix proteins, creating physical interactions between the cell surface and its surrounding scaffold. The extent and character of this attachment depend on the interacting surface chemistry and available contact area. Consequently, adhesive behavior is relevant to tissue organization and to research examining how cells establish relationships with their local environment.
Adhesive interactions help mucus and biological coatings remain associated with the surfaces they contact, while biomaterials can be designed or evaluated according to how they interact with biological interfaces. Examining attachment and spreading provides information about surface compatibility and performance. These considerations support research on tissue organization, biomaterials, and strategies for controlling cell-surface interactions.