Diabetes Research
Diabetes Research - Related Videos
10:43
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
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Cited by 98 •
2007
Our protocol was developed to cleanly and easily deliver islets or cells under the kidney capsule of mice. Cells are concentrated into pellets in the final tubing used for transplanting the cells under the kidney capsule. The ease of this technique reduces stress to the cells and the mouse.
16:26
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Cited by 2 •
2007
16:59
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
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Cited by 5 •
2012
We describe hepatic neo-islet formation in STZ (streptozotocin)-induced diabetic mice by gene transfer of Neurogenin3 (Ngn3) and Betacellulin (Btc) using helper-dependent adenoviral vector (HDAd) and the reversal of hyperglycemia. Our method takes advantages of helper-dependent adenoviral vectors with their highly efficient in vivo transduction and the long lasting gene expression.
15:18
Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
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Cited by 44 •
2013
We describe the adaptation of optical projection tomography (OPT)1 to imaging in the near infrared spectrum, and the implementation of a number of computational tools. These protocols enable assessments of pancreatic β-cell mass (BCM) in larger specimens, increase the multichannel capacity of the technique and increase the quality of OPT data.
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Cited by 69 •
2013
Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.
FAQs
Blood glucose regulation depends on both the amount of insulin produced and how effectively tissues respond to it. Diabetes research therefore examines impaired insulin production, reduced insulin sensitivity, or combinations of these changes rather than treating glucose imbalance as a single defect. Comparing these mechanisms helps researchers explain disease progression and evaluate which interventions may improve metabolic control.
Pancreatic beta cells are central because they produce insulin, making their function directly relevant to glucose regulation. Researchers study how beta-cell performance changes during disease development and whether treatments can preserve or restore it. These investigations connect cellular findings with broader goals, including improving glucose control, slowing progression, and supporting more targeted therapeutic strategies.
Genetic factors and immune responses provide two important biological perspectives on disease development. Researchers investigate how inherited influences may affect glucose metabolism or beta-cell function, while immune studies examine biological processes that may contribute to disruption. Combining these lines of evidence can clarify why diabetes develops differently among individuals and support more personalized approaches to prevention and treatment.
Diabetes research combines cellular, molecular, animal, clinical, and population-based approaches. Cellular and molecular studies examine mechanisms such as beta-cell function and glucose metabolism, whereas animal and clinical research evaluates disease progression and potential treatments. Population-based investigations add evidence about patterns across groups. Together, these methods connect biological mechanisms with outcomes relevant to prevention and care.
Researchers evaluate insulin replacement, glucose-lowering drugs, lifestyle interventions, and blood-sugar monitoring technologies using evidence from multiple research settings. Studies can examine biological effects, changes in glucose control, prevention of complications, or usefulness in individualized care. This progression from mechanism-focused work to clinical and population-based evaluation helps determine whether an approach can support metabolic health in practice.
Findings from genetics, glucose metabolism, immune responses, and clinical studies can reveal differences in how diabetes develops and progresses. Researchers use this knowledge to improve earlier identification of disease, match interventions to individual biological or clinical features, and monitor responses over time. The broader outcome is care that is more targeted while also addressing prevention and long-term complications.