Donor Skin Harvesting
Donor Skin Harvesting - Related Videos
04:25
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In this video, we demonstrate the extraction of articular cartilage from an equine cadaveric joint. The isolated articular cartilage can be used for further downstream analysis.
06:42
Murine Skin Transplantation
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Allogeneic skin transplantation is a standard model to assay host T cell responses to MHC-disparate donor antigens. This video-article provides a visual tutorial of each step involved in performing a BALB/c-->C57BL/6 skin transplant.
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Single Port Donor Nephrectomy
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12:29
Sterile Tissue Harvest
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Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN In 1959 The 3 R's were introduced by W.M.S. Russell and R.L. Burch in their book The Principles of Humane Experimental Technique. The 3 R's are replacement, reduction, and refinement of the use of animals in research. The use of cell lines and tissue cultures that originated from research animals is a replacement technique, as it allows for many experiments to be conducted in vitro. Harvesting...
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
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Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
FAQs
A dermatome removes the epidermis and only part of the dermis, leaving deeper tissue in place. This remaining tissue supports regeneration of the donor site’s surface rather than requiring replacement of the entire skin thickness. The balance between removing enough tissue for coverage and preserving deeper structures is therefore central to tissue repair.
Preserving deeper tissue maintains the biological foundation needed for the donor site to heal and regenerate its surface. If harvesting extended through all skin layers, the site would not retain the same tissue base described for split-thickness removal. This principle connects the surgical technique with skin biology and the body’s capacity for repair.
Successful graft integration depends on coordinated tissue repair, skin regeneration, and interaction between the transplanted tissue and the wound environment. The graft must remain positioned over the damaged area while the underlying tissue heals. Studying these processes helps explain why wound coverage is not only a physical replacement but also part of a broader repair response.
The procedure begins by selecting healthy skin from one body area as the donor tissue. A dermatome then excises a thin, split-thickness layer containing the epidermis and part of the dermis. The harvested tissue is subsequently placed over a wound or defect, while the donor area retains deeper tissue for surface regeneration.
Harvested skin may be used to cover burns, traumatic injuries, ulcers, and surgical defects. In each setting, the graft supplies coverage over damaged tissue and helps protect the underlying area while repair proceeds. These applications show why the technique is relevant across different forms of tissue loss rather than being limited to a single injury type.
Donor skin harvesting provides a model for examining how tissues repair themselves after controlled removal and transplantation. It allows biology studies to connect donor-site regeneration with graft integration and wound coverage. The process also highlights how tissue condition and healing-related factors can influence whether transplantation achieves effective protection and repair.