Embolic Stroke
Embolic Stroke - Related Videos
09:11
Embolic Middle Cerebral Artery Occlusion (MCAO) for Ischemic Stroke with Homologous Blood Clots in Rats
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Cited by 25 •
2014
In this paper, we demonstrate a standard method for producing an embolic middle cerebral artery occlusion with homologous blood clots (fibrin-rich) in adult rat. This model closely mimics human ischemic stroke and is suitable for preclinical study of thrombolytic therapy for ischemic stroke.
03:06
Combination of High Ligation and Intraoperative Embolization Using Polidocanol for Treatment of Varicoceles
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2023
To reduce the postoperative recurrence rate of varicocelectomy, we combined high ligation of varicocele with intraoperative embolization. We injected polidocanol from the spermatic vein during surgery to embolize the branches of the spermatic vein and collateral veins. This is an alternative surgical method for the treatment of varicocele.
01:29
Pulmonary Embolism I: Introduction
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2025
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
01:19
Pulmonary Embolism I: Introduction
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2026
A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
08:29
Microvascular Embolism Mouse Model for In Vivo Two-photon Microscopy Using Fluorescent Polystyrene Microspheres
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2025
This protocol contains a thorough description of a step-by-step approach for a chronic cranial window and microvascular embolism mouse model optimized for in vivo two-photon microscopy imaging using fluorescent polystyrene microspheres.
FAQs
Atrial fibrillation can be an important cardiac setting for embolus formation. An embolus may form in the heart, enter the bloodstream, and travel until it reaches a cerebral artery too narrow for passage. This pathway connects a cardiac condition with distant brain injury and explains why evaluation after an embolic stroke must consider possible sources outside the nervous system.
The key biological consequence is reduced delivery of oxygen and glucose beyond the blocked vessel. Downstream brain tissue consequently experiences a shortage of resources and may become damaged. This vascular mechanism explains why an embolic event can produce neurological injury, including weakness, speech difficulty, or vision loss, depending on the brain functions affected.
The embolus limits oxygen and glucose delivery to tissue beyond the cerebral vessel where it becomes lodged. Consequently, the affected vascular territory helps shape the neurological outcome. Injury in different regions can be associated with weakness, speech difficulty, or vision loss, making the relationship between vessel location, downstream tissue, and symptoms important in biology.
Urgent reperfusion treatment is important because the blocked circulation is depriving downstream brain tissue of oxygen and glucose. Addressing the interruption quickly supports efforts to restore blood delivery before additional tissue damage occurs. The mechanism therefore links the timing of treatment to the biological consequences of arterial blockage and sudden neurological injury.
Clinical evaluation and brain imaging help distinguish an embolic stroke from other stroke types. Assessment begins with the sudden neurological presentation, which may include weakness, speech difficulty, or vision loss, while imaging contributes information about the brain event. Together, these approaches support recognition of the event and selection of an appropriate urgent response.
Finding where the embolus formed is important because the source may lie outside the brain, including in the heart during atrial fibrillation. Source investigation helps connect the cerebral event to an underlying circulatory problem. That information supports targeted cardiovascular care intended to reduce the risk of another embolus and recurrent neurological injury.