Heart Apex Securing

Heart apex securing is a procedural technique that stabilizes the pointed lower region of the heart during experimental manipulation, imaging, or surgery. The method limits movement by gently fixing or supporting the apex in a defined position while maintaining access to the surrounding cardiac tissue and chambers. In biology research, this stabilization improves the consistency of cardiac measurements, dissections, injections, and microsurgical procedures by reducing motion-related error and tissue displacement. Reliable apex positioning can also support studies of heart structure, function, development, and disease, particularly when researchers need precise control of the organ during delicate experiments.

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Research

JoVE EoE - Rodent Models

Apical Resection Neonatal Mouse Model: A Surgical Procedure to Amputate the Ventricular Apex to Study Regenerative Potential in a Neonate Mouse Heart

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2025

In this video, we demonstrate the procedure to surgically remove the left ventricular apex of a neonatal mouse heart.

Education

JoVE Business - Finance

Secured Loans

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2025

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2024

The Security Market Line (SML) is a fundamental concept in finance that illustrates the relationship between an investment's expected return and its systematic risk, quantified by beta. This graphical representation helps investors understand how securities are priced based on their inherent risk levels and provides a framework for evaluating investment opportunities. The SML's slope, defined by the market risk premium, indicates the additional return investors require for taking on higher risk.

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2026

Issuing securities entails various costs, collectively referred to as issuance costs, which reduce the net proceeds a company receives. These costs depend on factors such as the type of security, issuance size, and prevailing market conditions.Key issuance costs include underwriting, legal, accounting, and registration fees. Underwriting fees compensate financial institutions that facilitate the sale of securities. Legal fees cover regulatory compliance, while accounting fees ensure...

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

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Cited by 12 •

2016

A step-by-step video protocol of apical resection is demonstrated in this study. Apical resection is a recently highlighted surgical approach in mammalian heart regeneration research. This study may promote the application of apical resection as a standard methodology in research into the mechanism underlying heart regeneration.

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