Hepatic Vascular Network
Hepatic Vascular Network - Related Videos
03:33
Visualization of Neural and Vascular Networks in a Chicken Embryo
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2025
Source: Delalande, J., et.al. Dual Labeling of Neural Crest Cells and Blood Vessels Within Chicken Embryos Using ChickGFP Neural Tube Grafting and Carbocyanine Dye DiI Injection. J. Vis. Exp. (2015)This video demonstrates the transplantation of a GFP-labeled donor neural tube from a stage-matched transgenic chicken embryo into a recipient embryo at the level of somites one to seven, followed by vascular labeling using a lipophilic fluorescent dye. The combined approach allows for direct...
10:53
Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks
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Cited by 10 •
2017
This protocol outlines the implementation of image-guided, laser-based hydrogel degradation to fabricate vascular-derived, biomimetic microfluidic networks embedded in poly(ethylene glycol) diacrylate (PEGDA) hydrogels. These biomimetic microfluidic systems may be useful for tissue engineering applications, generation of in vitro disease models, and fabrication of advanced "on-a-chip" devices.
06:00
Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
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2025
We present a laparoscopic technique for anatomic S7+S8d resection with right hepatic vein transection, preserving the inferior right hepatic vein and segment S6. Relying on meticulous anatomical landmarks without intraoperative ultrasound, this approach offers a precise and parenchyma-sparing option for dorsally located right-liver tumors, particularly in settings with limited advanced navigation resources.
07:56
A Comprehensive Rat Model For Assessing Hepatic Transport Pathways Through Simultaneous Lymphatic And Blood Vascular Sampling
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2026
This experimental protocol describes a hepatic lymph duct-cannulated rat model that enables direct and quantitative assessment of hepatic lymphatic and vascular drainage. The model allows simultaneous sampling of hepatic lymph and systemic blood to investigate hepatic transport, metabolism, and immune signaling, supporting studies of drug pharmacokinetics and liver-specific biology.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
FAQs
The two inflows create a dual-source supply with different contributions. The hepatic portal vein brings nutrient-rich blood, whereas the hepatic artery delivers oxygenated blood. Their streams meet and mix within liver sinusoids, allowing hepatocytes to receive both metabolic substrates and oxygen in the same exchange environment. This arrangement links nutrient delivery with the liver’s processing functions.
Sinusoids are the key exchange zone in the network. As mixed blood passes through them, hepatocytes exchange gases, nutrients, metabolites, and signaling molecules with the blood. That exchange provides the cellular interface required for metabolic processing and detoxification, while also allowing circulating substances to be modified before blood continues toward central veins and ultimately the hepatic vein.
Blood movement follows a directional sequence: portal and arterial blood enter, the streams mix in sinusoids, and the resulting blood drains toward central veins before reaching the hepatic vein. This organization is important because processing occurs before blood returns to the broader circulation, helping regulate which substances leave the liver and reenter circulating blood.
Because blood flows through a region of close functional contact with hepatocytes, vascular delivery supports more than oxygen transport. The arrangement supplies materials for metabolic activity, enables exchange involving metabolites and signaling molecules, and contributes to detoxification and bile production. It therefore connects circulation with multiple hepatic functions rather than serving as an isolated transport pathway.
In liver development and disease research, the network provides a framework for examining how blood supply relates to hepatic function. Its dual inflow, sinusoidal exchange region, and venous drainage connect vascular organization with nutrient processing, detoxification, bile production, and control of circulating substances. Studying these linked features keeps vascular and metabolic questions connected.
Drug metabolism studies must account for how blood reaches hepatocytes and how processed blood returns to circulation. The network is relevant because portal and arterial inputs deliver distinct blood characteristics, while sinusoidal exchange exposes hepatocytes to metabolites and signaling molecules. This context helps relate vascular handling to the liver’s role in processing circulating substances.
In vascularized tissue models, reproducing the hepatic network matters because liver function depends on coordinated blood delivery, sinusoidal exchange, and drainage. A model that represents these linked features can be used to study liver biology in a context that includes nutrient-rich portal input, oxygenated arterial input, hepatocyte exchange, and venous outflow. The network is therefore central to model relevance.