Hydrogel Polymerization

Hydrogel polymerization is the process of forming water-rich, three-dimensional polymer networks that can absorb and retain substantial amounts of water while maintaining their structure. It typically proceeds when water-compatible monomers or macromers undergo chain-growth or step-growth reactions, creating covalent or physical crosslinks that control the gel’s strength, swelling, and porosity. In biology, hydrogel polymerization supports the development of cell culture matrices, drug delivery systems, biosensors, and tissue-engineering scaffolds. By adjusting polymer composition, crosslink density, and reaction conditions, researchers can produce materials with properties suited to cell encapsulation, biomolecule transport, and controlled biological interactions.

Hydrogel Polymerization - Related Videos

Research

JoVE Journal - Chemistry
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Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Cited by 32 •

2013

This video will illustrate a rapid, efficient method to methacrylate poly(ethylene glycol), enabling chain polymerizations and hydrogel synthesis. It will demonstrate how to similarly introduce methacrylamide functionalities into peptides, detail common analytical methods to assess functionalization efficiency, provide suggestions for troubleshooting and advanced modifications, and demonstrate typical hydrogel characterization techniques.

Education

JoVE Science Education - Engineering

Collagen Hydrogels

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2023

Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...

Hydrogel Synthesis

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2023

Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...

Polymerization

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2023

Source: Vy M. Dong and Jan Riedel, Department of Chemistry, University of California, Irvine, CA Polymers are made from macromolecules, which are composed of repeating units (the so called monomeric units). In our modern world, polymers play an important role. One of the first important polymers was nylon, which is a polyamide. It found widespread application in tooth brushes and stockings.

Photochemical Initiation Of Radical Polymerization Reactions

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2023

Source: David C. Powers, Tamara M. Powers, Texas A&M In this video, we will carry out the photochemically initiated polymerization of styrene to generate polystyrene, which is an important commodity plastic. We will learn the fundamentals of photochemistry and use simple photochemistry to initiate radical polymerization reactions. Specifically, in this module we will examine the photochemistry of benzoyl peroxide and its role as a photo-initiator of styrene polymerization reactions. In the...

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