Irreversible Learning
Irreversible Learning - Related Videos
03:50
Irreversible Electroporation: A Technique for Ablating Pancreatic Tumor in Mouse
0 Views •
2023
This video describes the procedure for performing irreversible electroporation (IRE) for non-thermal ablation of pancreatic tumors in mice. Both subcutaneous (SQ) and orthotopic tumors can be successfully treated with IRE in a highly controlled setting, facilitating various studies post-procedure.
14:05
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
0 Views •
Cited by 47 •
2014
The murine model of irreversible unilateral ureteric obstruction (UUO) is presented together with the model of reversible UUO in which the ureteric obstruction is relieved by anastomosis of the severed ureter into the bladder. These models enable the study of renal inflammation and scarring as well as tissue remodeling.
01:14
Reversible and Irreversible Processes
0 Views •
2023
The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
06:17
Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
0 Views •
2025
The quantitative irreversible tethering (qIT) assay is a fluorescence-based method of identifying covalent fragments that selectively engage with a target protein. Here, a detailed protocol is outlined to describe the qIT assay, with example results included.
10:06
An Introduction to Learning and Memory
0 Views •
2023
Learning is the process of acquiring new information and memory is the retention or storage of that information. Different types of learning, such as non-associative and associative learning, and different types of memory, such as long-term and short-term memory, have been associated with human behaviors. Studying these components in detail helps behavioral scientists understand the neural mechanisms behind these two complex phenomena. JoVE's overview on learning and memory introduces common...
FAQs
Long-term potentiation, or LTP, strengthens communication between neurons, whereas long-term depression, or LTD, weakens it. These opposing changes can modify how neural circuits respond to later stimuli. In Irreversible Learning, altered synaptic strength provides a cellular basis for retaining an acquired response rather than allowing behavior to return readily to its previous state.
Changes in synaptic strength may not remain stable without longer-term cellular support. Experience can alter gene expression and promote protein synthesis, supplying processes that help maintain modified neural connections. These mechanisms extend learning beyond a short-lived synaptic adjustment and help explain why some experience-dependent changes persist in nervous-system function.
Structural remodeling changes the physical organization of neural circuits after experience. When connections or circuit features are reshaped, later signaling may follow a modified pathway rather than the original one. This added level of change helps account for resistance to simple reversal and links persistent behavior with lasting anatomical or circuit-level adaptation.
The key distinction is persistence. A transient adaptation may fade when the stimulus changes or stops, while Irreversible Learning remains resistant to simple reversal. Researchers therefore examine whether experience has produced enduring behavioral or nervous-system changes, rather than treating every short-term adjustment as evidence of lasting memory formation.
Researchers use the concept to connect observable behavior with persistent changes in neural circuits. They can consider whether altered synaptic strength, gene expression, protein synthesis, or structural remodeling accompanies a durable response. This framework helps separate temporary adaptation from memory-related change and clarifies how experience can shape behavior over time.
Persistent experience-dependent changes can support useful behavior, but they can also contribute to maladaptive behavior. In addiction research, the framework focuses attention on durable neural and behavioral effects of experience. In rehabilitation, it highlights the importance of lasting circuit changes when considering how function may be supported or behavior may be reshaped over time.