Kidney Graft
Kidney Graft - Related Videos
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Cited by 43 •
2015
The severe organ shortage has resulted in increased use of marginal kidney grafts for transplantation. This has triggered interest in alternative storage methods, since marginal grafts especially tolerate cold storage poorly. The technique of normothermic ex vivo kidney perfusion (NEVKP) represents a novel preservation method for kidney grafts prior to transplantation.
04:43
Orthotopic Porcine Kidney Transplantation: A Technique to Transplant Graft Kidney in Porcine Model
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2025
This video describes orthotopic kidney auto-transplantation in a porcine model. This surgical procedure involves the transplantation of an animal's kidney graft at its original anatomical location. The model is used to investigate new treatments for end-stage kidney diseases in humans.
02:34
Modeling Preservation Injury in Porcine Donor Kidney: A Procedure to Induce Graft Dysfunction by Subjecting Kidney to Prolonged Cold Ischemia
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2025
In this video, we describe a technique to induce preservation injury via the prolonged cold ischemic storage time in porcine donor kidney.
02:48
Nephrectomy in a Porcine Model: A Surgical Procedure to Retrieve Porcine Kidney Graft for Transplantation
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2025
This video demonstrates nephrectomy, the surgical procedure to remove one of the kidneys along with the section of the ureter. The blood vessels to and from the kidney are tied and divided. The excised kidney can be used for transplantation procedures.
10:42
Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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2026
This protocol describes the ex vivo normothermic machine perfusion of a rat kidney for subsequent transplantation into a recipient rat.
FAQs
Donor antigens are features that can be recognized as foreign by the recipient’s immune system. That recognition can activate an immune response against graft tissue, creating the biological basis of rejection. Compatibility studies and post-transplant monitoring therefore focus on how the recipient and donor interact immunologically, not only on whether the surgical connections function.
Immunosuppressive drugs reduce the immune response that can damage a graft, but stronger or prolonged suppression can increase treatment-related risks, including infection. Clinical care therefore requires a balance: enough medication to limit rejection while avoiding unnecessary harm. This trade-off makes drug management a central biological and medical problem in maintaining graft function over time.
Successful surgical connections provide two essential routes for the transplanted organ. Blood-vessel connections allow the kidney graft to receive circulation, while the ureter connection provides a pathway for urine produced by the kidney. Together, these anatomical links connect the graft to the recipient’s physiology and allow clinicians to assess whether the transplanted organ is functioning.
Surgeons connect the graft’s blood vessels and ureter to structures in the recipient so the transplanted kidney can participate in circulation and urine handling. This procedure links donor anatomy with the recipient’s renal system. Its biological success depends on restoring these pathways while the clinical team also manages the recipient’s immune response to donor tissue.
Kidney graft research brings together anatomy, physiology, immunology, and medicine in one clinical system. It allows investigators to examine how organ structure supports function, how immune recognition can cause rejection, and how treatment changes that response. This combined perspective supports work on tissue compatibility, transplant monitoring, and strategies intended to improve long-term graft survival.
They focus on whether the graft receives circulation, produces urine, and continues to support renal function, while also watching for immune rejection and treatment-related complications such as infection. These outcomes connect observable clinical performance with underlying biological mechanisms. Over longer periods, the same assessments contribute to understanding graft survival and improving care for end-stage kidney disease.