Left Atrial Ligation
Left Atrial Ligation - Related Videos
23:33
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Cited by 49 •
2012
The accompanying video describes a procedure for percutaneous placement of the WATCHMAN Left Atrial Appendage (LAA) Device. The WATCHMAN is a nitinol device designed to be permanently implanted at, or slightly distal to, the opening of the left atrial appendage (LAA) to trap blood clots before they exit the LAA, preventing thromboembolic stroke.
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Cited by 11 •
2013
Catheter ablation is combined with placement of the WATCHMAN Left Atrial Appendage Closure Device to prevent ischemic stroke in a patient with non-valvular atrial fibrillation.
04:37
Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development
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Cited by 3 •
2023
Here, we present a detailed visual protocol for executing the left atrial ligation (LAL) model in the avian embryo. The LAL model alters the intracardiac flow, which changes wall shear stress loading, mimicking hypoplastic left heart syndrome. An approach to overcome the challenges of this difficult microsurgery model is presented.
07:28
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
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2024
This protocol describes a new method for effectively reconstructing donor atrial cuff anterior wall defects during lung transplantation through the rotation of the donor posterior atrial flap.
06:25
Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation
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Cited by 6 •
2020
The goal of this protocol is to describe the use of esophageal temperature modulation to counteract esophageal thermal injury from left atrial ablation for the treatment of atrial fibrillation.
FAQs
The immediate consequence is a shift in local pressure, volume, and flow patterns. By mechanically isolating the targeted region from the circulating blood pool, ligation changes the hemodynamic environment associated with that structure. These alterations allow investigators to connect a defined anatomical intervention with subsequent changes in cardiac function and chamber remodeling.
The selected target determines which portion of the left-sided atrial system is mechanically isolated and therefore which local pressure, volume, and flow changes are examined. Because the technique can focus on either the atrium or its appendage, researchers can relate the site of intervention to chamber remodeling, blood stasis, and thrombus-forming mechanisms.
Ligation creates altered flow conditions within the affected atrial region, making it possible to study how disrupted circulation relates to blood stasis. Investigators can then examine whether changes in local pressure, volume, and flow accompany mechanisms that contribute to thrombus formation. This links cardiac structure and hemodynamics with a clinically important biological outcome.
Assessment should focus on the variables identified as directly affected by the intervention: local pressure, chamber volume, flow patterns, and overall cardiac function. Observing these factors together helps distinguish an immediate hemodynamic response from later structural remodeling. The combined measurements provide a biological framework for interpreting how atrial isolation changes cardiac performance.
The central procedural step is placing a suture or ligature around the selected left atrial structure. The intervention mechanically isolates that region from the circulating blood pool. Researchers can then evaluate changes in pressure, volume, flow, cardiac function, and chamber remodeling, using the resulting pattern to investigate atrial physiology and impaired left atrial function.
Researchers may use the model to investigate atrial physiology, chamber remodeling, blood stasis, and mechanisms associated with thrombus formation. It is also relevant when studying cardiac injury or evaluating therapeutic interventions. By producing a defined change in atrial circulation and function, the approach supports experiments that connect structural alteration with cardiovascular outcomes.
Because the intervention produces altered left atrial pressure, volume, flow, and function, it can serve as an experimental context for testing responses to therapeutic interventions. Studies may also evaluate procedures intended to prevent complications associated with impaired left atrial function. Outcomes can be interpreted through changes in remodeling, stasis, thrombus-related mechanisms, or cardiac performance.