Magnetic Particle Concentrator
Magnetic Particle Concentrator - Related Videos
02:41
Concentration and Purification of Viral Particles
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2026
Source: Fricano-Kugler, C. J., et al. Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection. J. Vis. Exp. (2016).This video demonstrates the step-by-step process for concentrating and purifying lentiviral particles from a mixed suspension containing host cell debris. The procedure utilizes centrifugation, filtration, and PEG-salt precipitation to isolate viral particles while removing soluble impurities. The final product is resuspended in a...
07:01
Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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Cited by 5 •
2016
A scanner for imaging magnetic particles in planar samples was developed using the planar frequency mixing magnetic detection technique. The magnetic intermodulation product response from the nonlinear nonhysteretic magnetization of the particles is recorded upon a two-frequency excitation. It can be used to take 2D images of thin biological samples.
03:06
Growth and Differentiation of Magnetic Nano Particle-Loaded Neurons on Magnetic Platforms
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2025
This video demonstrates the uptake of fluorescent magnetic nanoparticles (MNPs) by the neuronal cells via endocytosis. Growing these MNP-loaded neurons on the magnetically patterned substrate enables the attachment of the cells. The addition of a growth factor containing medium aids in the growth of neuron extensions, while the magnetic field of the substrate directs the orientation of the extension.
03:43
A Technique for Magnetic Glass Particle-Mediated Nucleic Acid Extraction from Blood
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2025
This video demonstrates a technique for nucleic acid extraction from whole human blood using magnetic glass particles (MGPs) — small magnetic beads coated with silica. Upon lysing the blood cells using a lysis buffer, the released nucleic acids bind to the surface of silica-coated MGPs, extracting the molecules from the sample.
01:22
Motion Of A Charged Particle In A Magnetic Field
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2023
A charged particle experiences a force when moving through a magnetic field. Consider the field to be uniform and the charged particle to move perpendicular to it. If the field is in a vacuum, the magnetic field is the dominant factor determining the motion. Since the magnetic force is perpendicular to the direction of motion, a charged particle follows a curved path. The particle continues to follow this curved path until it forms a complete circle. Another way to look at this is that the...
FAQs
The field does not collect every component of the sample equally. Magnetically responsive particles move toward the nearby collection surface, while the surrounding nonmagnetic liquid and materials remain available for removal. When cells, proteins, nucleic acids, or other biomolecules are associated with magnetic beads, this movement provides the physical basis for concentrating them.
A field gradient is important because it directs particle migration toward a defined location rather than merely exposing the sample to magnetism. The concentrator places the field close to the fluid, allowing bead-associated material to be retained at a collection surface. This localized retention supports separation from the liquid during downstream handling.
Washing and aspiration separate retention from purification. After magnetically responsive material has been held in place, the nonmagnetic liquid and other materials can be removed, and washing can be performed before another removal step. This reduces the amount of non-target sample carried forward and supports cleaner preparation for later biological workflows.
Basic operation starts by placing the magnetic field or field gradient near the sample. Responsive particles then migrate to the collection surface, where they are retained while nonmagnetic liquid is removed through aspiration or washing. The retained fraction can subsequently serve as the isolated or purified material for a biological research workflow.
Magnetic particle concentrators can support workflows involving cells, proteins, nucleic acids, and other biomolecules. The same physical collection principle therefore serves both cellular and molecular biology tasks. In practice, the device is relevant when a researcher needs to isolate or purify magnetically associated material from a fluid rather than process the entire sample uniformly.
Reduced handling and shorter processing time make the approach useful when sample preparation must be efficient. Magnetic particle concentration is relevant to cell separation, molecular biology workflows, diagnostics, and automated laboratory systems. Its value in these settings comes from retaining bead-associated material while the surrounding fluid and removable materials are taken away.