Mouse Fetus

A mouse fetus is the developing offspring of Mus musculus during the prenatal stage, when embryonic tissues mature into organized organs and body systems. Within the uterus, coordinated cell division, migration, differentiation, and signaling shape tissues under genetic and environmental control, while the placenta supports the exchange of oxygen, nutrients, and waste products between the mother and fetus. Mouse fetuses are widely used in developmental biology because their staged development, well-characterized genetics, and experimental accessibility allow researchers to investigate organ formation, congenital abnormalities, toxicant effects, and gene function. These studies also support disease modeling and evaluation of developmental therapies.

Mouse Fetus - Related Videos

Education

JoVE Core - Anatomy and Physiology

Development of the Sexual Organs in the Embryo and Fetus

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2024

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development. Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

Research

JoVE Journal - Medicine

A Mouse Model of in Utero Transplantation

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Cited by 26 •

2011

The mouse model of in utero transplantation is a versatile tool that can be used to study the potential clinical applications of stem cell transplantation and gene therapy in the fetus. In this protocol, we present a general approach to performing this...

A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model

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Cited by 8 •

2012

We developed a novel surgical approach for intratracheal administration of bioactive agents into the mouse fetus. The delivery route is more efficient in targeting the fetal mouse lungs than the commonly used intra-amniotic injection. This procedure has to date not been described in a mouse model.

A Mouse Fetal Skin Model of Scarless Wound Repair

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Cited by 24 •

2015

During mammalian development, early gestational skin wounds heal without a scar. Here we detail a reliable and reproducible model of fetal scarless wound healing in the cutaneous dorsum of E16.5 (scarless) and E18.5 (scarring) mouse embryos.

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

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2023

The present protocol describes a method to deliver drugs and gene expression-modifying agents perivascularly in an in utero developing fetus. Importantly, the effect of drugs/agents on blood flow can be measured with the progression of pregnancy.

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