Multicellular Organisms

Multicellular organisms are living systems composed of many cells that coordinate their activities to perform functions a single cell cannot accomplish, making them central to the study of biological organization. They develop through repeated cell division, followed by cell differentiation, adhesion, and chemical signaling that establish specialized cell types, tissues, organs, and interacting body systems. In biology, studying multicellular organisms reveals how genes and cells control development, homeostasis, reproduction, and responses to environmental change. These principles support research on evolution, disease, regenerative medicine, and tissue engineering, where disrupted communication or differentiation can contribute to developmental disorders or cancer.

Multicellular Organisms - Related Videos

Research

JoVE Journal - Bioengineering

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

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2022

The present protocol describes the design, fabrication, and characterization of a microfluidic system capable of aligning, immobilizing, and precisely compressing hundreds of Drosophila melanogaster embryos with minimal user intervention. This system enables high-resolution imaging and recovery of samples for post-stimulation analysis and can be scaled to accommodate other multicellular biological systems.

Caenorhabditis Sieve: A Low-tech Instrument and Methodology for Sorting Small Multicellular Organisms

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Cited by 5 •

2018

The current protocol includes a methodology for the sorting and cleaning of age-matched populations of Caenorhabditis elegans. It uses a simple, inexpensive, and efficient custom-made tool to obtain a large experimental population of nematodes for research.

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

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Cited by 12 •

2013

To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.

Generation of Multicellular Human Primary Endometrial Organoids

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Cited by 37 •

2019

A protocol to generate human primary endometrial organoids that consist of epithelial and stromal cells and retain characteristics of the native endometrial tissue is presented. This protocol describes methods from uterine tissue acquisition to the histologic processing of endometrial organoids.

Education

JoVE Core - Anatomy and Physiology
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Exocrine Glands: Unicellular and Multicellular Glands

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2025

Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...

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