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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

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6,020 Views

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12:38 min

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December 18, 2013

DOI:

10.3791/50840-v

DOI:
10.3791/50840-v

•

12:38 min
December 18, 2013

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1 Views
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1Department of Life Sciences, National Institute for Biotechnology in the Negev,Ben-Gurion University of the Negev

Summary

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To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.

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Cite this Article

Karady, I., Frumkin, A., Dror, S., Shemesh, N., Shai, N., Ben-Zvi, A. Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism. J. Vis. Exp. (82), e50840, doi:10.3791/50840 (2013).

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