Neoplasms
Neoplasms - Related Videos
10:10
Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
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2026
This protocol presents robotic duodenum-preserving total pancreatic head resection (R-DPPHRt) for intraductal papillary mucinous neoplasms (IPMNs). A video demonstrates the technique in a patient with main duct-IPMN, highlighting its feasibility as a minimally invasive, organ-preserving alternative to pancreaticoduodenectomy.
08:12
Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
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Cited by 5 •
2016
This manuscript provides a description of the methodology used to establish transduction-transplantation mouse models. A detailed account is given of technical errors to avoid when performing bone marrow transplants. A clear understanding should be gained of the importance of high viral titer, transfection/transduction, and irradiation.
08:14
Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
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Cited by 10 •
2017
Mosaic clone analysis in Drosophila imaginal disc epithelia is a powerful model system to study the genetic and cellular mechanisms of tumorigenesis. Here we describe a protocol to induce tumors in Drosophila wing imaginal discs using the GAL4-UAS system, and introduce a diagnosis method to classify the tumor phenotypes.
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
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2019
This article describes a method to identify clonal and subclonal alterations among different specimens from a given patient. Although the experiments described here focus on a specific tumor type, the approach is broadly applicable to other solid tumors.
10:41
Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations
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Cited by 5 •
2017
Wild-type blocking PCR followed by direct sequencing offers a highly sensitive method of detection for low frequency somatic mutations in a variety of sample types.
FAQs
Neoplastic growth becomes biologically significant when genetic and epigenetic changes alter several coordinated controls rather than a single division signal. These changes can affect cell division, differentiation, survival, and communication with surrounding tissue. Examining which controls are disrupted helps biologists explain how abnormal growth is maintained and why different neoplasms can show different behaviors.
Malignant behavior is linked not only to continued proliferation but also to altered interactions with surrounding tissue. A neoplasm may invade nearby structures and, during progression, reach other sites through blood or lymphatic systems. Studying these properties helps distinguish patterns of tissue damage and spread from growth that remains localized.
The tumor microenvironment and immune response provide context for how neoplasms develop and progress. Surrounding tissue interactions may influence the behavior of abnormal cells, while immune responses can be examined in relation to disease development and treatment response. Including these factors gives researchers a broader biological view than studying proliferating cells alone.
In biology, classification organizes neoplasms according to their tumor characteristics, while molecular investigation seeks cancer-associated genetic and epigenetic changes. This pairing connects what a neoplasm does with alterations that may help explain it. The resulting framework supports more precise study of development, progression, and clinically relevant differences.
Diagnostic methods help identify cancer-associated molecular changes and support the classification of tumors. Their value extends beyond recognizing an abnormal mass because they can connect tumor status with biological alterations under investigation. This information supports research into how neoplasms develop and provides a basis for evaluating disease-related differences and treatment possibilities.
Targeted treatments are investigated because neoplasms can contain cancer-associated molecular changes that disrupt normal cellular controls. Linking those changes to tumor behavior may reveal treatment opportunities directed toward relevant biological features. Researchers also examine treatment response, allowing molecular findings, tumor progression, and the surrounding microenvironment to be considered together when evaluating therapeutic outcomes.