Organ Transplant
Organ Transplant - Related Videos
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Cited by 2 •
2017
Mismatches in human leukocyte antigen (HLA) sequences between organ donor and recipient pairs are the major cause of antibody-mediated rejection in organ transplantation. Here we present the use of custom antigen arrays that are based on individual donors' HLA sequences to probe anti-donor HLA alloantibodies in organ recipients.
08:15
Cervical Heterotopic Mouse Heart Transplantation using End-to-side Anastomosis Technique to Study Transplant Immunology
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2026
This protocol presents a simplified, end-to-side suture anastomosis technique for murine cervical heart transplantation, providing a robust and reproducible model for studying transplant immunology.
08:15
Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
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2025
Donor heart preservation is a major determinant of success in heart transplantation. Technological advances have led to optimizing the conditions of preservation, along with a more accurate assessment of the donor heart before transplantation. We herein describe two innovative technologies currently applied for cardiac preservation: uniform cooling preservation and normothermic ex-situ heart perfusion.
08:37
Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
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2025
Here, we present a protocol to establish a long-term liver cold storage and transplantation model in Daurian ground squirrel (DGS), which has been technically challenging in standard rodent models.
FAQs
Human leukocyte antigen, or HLA, matching helps compare immune-related markers between donor and recipient. Greater compatibility can reduce the likelihood that the recipient’s immune system will recognize the transplanted tissue as sufficiently different to trigger damaging responses. Along with blood-group compatibility, HLA matching therefore contributes to evaluating whether a donor organ is biologically suitable for a recipient.
Rejection can occur when the recipient’s immune system identifies donor tissue as foreign. T cells may become activated and contribute to an immune attack, while antibodies can also damage the transplanted organ. These responses illustrate how immune recognition and inflammation influence host-graft interactions, making rejection a central biological challenge in maintaining organ function after transplantation.
Immunosuppressive drugs reduce immune activity directed against the donor organ, particularly T-cell activation and antibody-mediated attacks. This lowers the biological processes that can produce rejection and helps preserve the graft’s function. However, immune suppression requires lifelong management and is associated with infection risk, so maintaining transplant success involves balancing protection of the organ with the recipient’s broader health.
Success depends strongly on compatibility between the donor and recipient, especially blood-group and HLA matching. The recipient must also maintain treatment that limits immune attacks after surgery. These factors interact with the organ’s ability to restore physiological function, so transplantation outcomes reflect both initial biological suitability and continued control of host-graft immune responses.
Beyond treating organ failure, transplantation provides a model for investigating immune recognition, inflammation, tissue repair, and interactions between a host and a graft. Researchers can use these biological relationships to examine how recipient tissues respond to transplanted material and how immune processes influence graft survival. This makes transplantation relevant to several connected areas of biology and medicine.
Organ transplantation is used when disease or injury has damaged an organ enough to cause end-stage organ failure. Replacing the failing tissue can restore essential physiological function, but treatment is constrained by the availability of suitable donor organs. Recipients also face infection risk and the need for lifelong immune management, which remain important practical limitations.