Pulsatile Blood Flow
Pulsatile Blood Flow - Related Videos
10:02
Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
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Cited by 12 •
2011
The following protocol outlines the process of isolating, ventilating and instrumenting mouse lungs to measure steady or pulsatile pulmonary vascular pressure-flow relationships in order to quantify the effects of blood flow, airflow, airway changes and vascular changes on right ventricular afterload.
03:38
Developing a Cerebral Blood Flow Atlas for Blood Flow Mapping
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2025
Source: Tan, Z., et al., Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling. J. Vis. Exp. (2024).This video demonstrates the method to construct a cerebral blood flow atlas by integrating magnetic resonance imaging or MRI-arterial spin labeling data with segmented brain regions, visualizing blood flow patterns, and quantifying flow levels across functional areas.
01:29
Blood Flow
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2025
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow. Slow...
11:22
Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor
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Cited by 32 •
2011
Our group has developed a bioreactor culture system that mimics the physiological pulsatile stresses of the cardiovascular system to regenerate implantable small-diameter vascular grafts.
07:30
In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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Cited by 6 •
2015
This protocol replicates physiological or pathological blood flow in vitro to aid in determining cell response in disease pathologies. By introducing a pressure damping chamber downstream of a blood pump, blood flow across the vasculature can be recapitulated and imposed on a monolayer of vascular endothelium or a mimetic co-culture.
FAQs
The heart’s alternating phases create more than a simple change in flow rate: ventricular contraction produces a pressure wave that travels along the arteries, while relaxation changes conditions between beats. Examining both pressure and velocity helps distinguish the traveling wave from the continuing movement of blood, clarifying how circulation is maintained throughout the cardiac cycle.
Arterial elasticity acts as an energy buffer. During ventricular contraction, arterial walls temporarily store energy; between beats, they release it to support forward movement. This buffering helps maintain flow during the heart’s relaxation phase, making elasticity an important factor when interpreting how pulsatile blood flow continues through the arteries rather than stopping after each contraction.
Changes in pressure, velocity, and wall stress are linked rather than independent observations. Together, they show how the pulse affects vessel walls and how blood is distributed through the circulation. Considering these variables together is useful because vascular function and oxygen delivery depend on the mechanical behavior of blood as it moves through the circulatory system.
An analysis should consider changes in pressure, velocity, and wall stress across the cardiac cycle rather than relying on one value. These variables reveal how the pressure wave moves, how arterial elasticity supports flow between beats, and how vessels experience circulation. The combined information can support assessment of vascular function and blood distribution.
Blood pressure is part of a time-varying process, not an isolated feature of circulation. Relating pressure readings to ventricular contractions, arterial energy storage, and the traveling pressure wave provides physiological context for each measurement. This perspective helps researchers interpret blood-pressure data alongside vascular function and the continuing delivery of blood to tissues.
Models and devices intended to represent or interact with circulation must account for rhythmic pressure and flow changes, arterial elasticity, and wall stress. Studying pulsatile blood flow supplies that context, helping researchers evaluate whether a model reflects cardiovascular physiology and whether device-related analyses consider realistic conditions of blood movement through the circulatory system.