Umbilical Artery Flow
Umbilical Artery Flow - Related Videos
08:06
Isolation of Human Umbilical Arterial Smooth Muscle Cells (HUASMC)
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Cited by 8 •
2010
The umbilical cords are used to isolate smooth muscle cells by different ways. In this work we used the enzymatic treatment to isolated smooth muscle cells.
08:54
Isolation of Human Umbilical Vein Endothelial Cells and Their Use in the Study of Neutrophil Transmigration Under Flow Conditions
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Cited by 33 •
2012
This article first describes a procedure for isolating human endothelial cells from umbilical veins and then shows how to use these cells to examine neutrophil transmigration under flow conditions. By using a low-volume flow chamber made from a polymer with the optical characteristics of glass, live-cell fluorescent imaging of rare cell populations is also possible.
09:19
Isolation of Human Umbilical Vein Endothelial Cells (HUVEC)
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Cited by 129 •
2007
This video protocol illustrates the isolation and culture of human umbilical vein endothelial cells (HUVEC) from human umbilical cord. Once isolated these cells can be used for in vitro angiogenesis assays like the Optimized Fibrin Gel Bead Assay also demonstrated by the Hughes lab.
06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Cited by 20 •
2015
Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.
09:40
Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats
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Cited by 11 •
2016
Non-invasive assessment of endothelial function in humans can be determined by the flow-mediated dilation technique. Although thousands of studies have used this technique, no study has performed this technique non-invasively in rats. The following article describes non-invasive measurement of flow-mediated dilation in the brachial and superficial femoral arteries of rats.
FAQs
Fetal cardiac contraction provides the driving force that moves blood through the umbilical arteries toward the placenta. This movement delivers relatively deoxygenated fetal blood and metabolic waste to placental capillaries, where exchange with the maternal circulation can occur. Changes in cardiac pumping therefore affect the blood-flow pattern reaching the placenta.
Placental vascular resistance influences how readily blood moves through the placental circulation. Higher or altered resistance can affect the speed and pattern of blood flow recorded in the umbilical arteries. Because the placenta is the site of exchange with maternal circulation, these flow characteristics provide information about how effectively fetal blood can reach the exchange region.
Blood traveling through the umbilical arteries is relatively deoxygenated and carries metabolic waste from the fetus toward placental capillaries. This direction of transport supports removal of waste and prepares the blood for exchange with the maternal circulation. The placenta then serves as the interface through which oxygen and nutrients can support fetal needs.
Impaired placental circulation can indicate that the pathway supporting fetal oxygen and nutrient delivery is not functioning normally. Measuring umbilical artery flow provides a way to examine this circulation without directly accessing the fetus. Abnormal findings may therefore help identify placental problems that could affect fetal growth or well-being.
Doppler ultrasound measures the velocity of blood moving through the umbilical arteries and evaluates resistance within the circulation. The technique is noninvasive, so it can be used repeatedly during pregnancy to observe placental blood-flow patterns. These measurements give clinicians biological information about placental function without requiring direct sampling of fetal blood.
Monitoring is useful when pregnancy complications may affect placental circulation, oxygen delivery, or nutrient supply. Serial Doppler measurements can contribute to assessment of fetal growth and well-being over time. The findings may also help guide clinical decisions when the circulation between the fetus and placenta appears impaired.
Umbilical artery Doppler results can provide evidence about placental resistance and the adequacy of fetal blood delivery to the placental exchange region. Interpreted alongside concerns about fetal growth and pregnancy complications, these results support evaluation of placental function. They can help identify pregnancies requiring closer monitoring and inform decisions about ongoing care.