Vascular Studies
Vascular Studies - Related Videos
08:53
The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
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Cited by 38 •
2016
We describe a microsurgical approach for the generation of an arteriovenous (AV) loop as a model for analyzing vascularization in vivo in an isolated and well-characterized environment. This model is not only useful for the investigation of angiogenesis, but is also optimally suited for engineering axially vascularized and transplantable tissues.
09:06
Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
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Cited by 7 •
2012
We describe a technique in which a section of the abdominal aorta from a mouse is transplanted orthotopically to just below the renal arteries in an allogeneic or syngeneic recipient. This technique can be useful in studies in which transplantation of large arteries of uniform size is deemed advantageous.
01:19
Imaging Studies VII: Vascular Imaging
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2025
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
09:53
Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
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Cited by 19 •
2011
We introduce a whole-mount immunohistochemistry and laser scanning confocal microscopy with multiple labelling for analyzing intricate vascular network formation in mouse embryonic limb skin.
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
FAQs
They assess how endothelial cells regulate vessel permeability and how smooth muscle contributes to changes in vessel diameter. These functions affect the movement of substances across vessel walls and the distribution of blood through tissues. Examining both cell types helps researchers connect cellular behavior with broader physiological processes, including regulated circulation and vascular responses in health and disease.
Angiogenesis describes the formation of new blood vessels, whereas vasoconstriction narrows existing vessels by reducing their diameter. Studying these contrasting processes helps reveal how vascular networks develop and how blood flow is adjusted. Their analysis is particularly relevant when researchers investigate normal development, tissue repair, or disease-associated changes in vascular structure and function.
Vascular outcomes depend on interactions among endothelial cells, smooth muscle, and surrounding tissues. These components can influence how readily substances cross vessel walls, how wide vessels become, and how blood moves through them. Vascular Studies therefore examine structure and function together rather than treating blood flow as an isolated measurement, allowing cellular and tissue-level regulation to be considered in context.
Researchers combine imaging, cell culture, molecular assays, and physiological measurements to investigate vascular behavior from multiple perspectives. Imaging can examine vessel structure, while cell culture supports analysis of cellular responses. Molecular assays assess relevant biological changes, and physiological measurements evaluate functional outcomes. Using these approaches together connects observed molecular or cellular activity with vascular performance.
They are used to examine how vessels form and function during normal development and how those patterns change in disease. Comparisons can focus on vascular structure, permeability, diameter, or blood flow, as well as responses involving surrounding tissues. This approach helps identify differences associated with inflammation, cancer, cardiovascular disease, or impaired tissue repair.
By linking vascular dysfunction with inflammation, cancer, cardiovascular disease, and impaired tissue repair, these studies help clarify how abnormal circulation contributes to disease. Researchers can use findings from imaging, molecular analysis, and physiological assessment to identify vascular changes relevant to diagnosis or treatment. The resulting knowledge supports development of diagnostic approaches and targeted therapies.