Vascular System Development
Vascular System Development - Related Videos
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
08:22
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
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Cited by 37 •
2017
We provide a generalized protocol based on a microfluidic bioprinting strategy for engineering a microfibrous vascular bed, where a secondary cell type could be further seeded into the interstitial space of this microfibrous structure to generate vascularized tissues and organoids.
07:24
Development of the Chick
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2023
The chicken embryo (Gallus gallus domesticus) provides an economical and accessible model for developmental biology research. Chicks develop rapidly and are amenable to genetic and physiological manipulations, allowing researchers to investigate developmental pathways down to the cell and molecular levels. This video review of chick development begins by describing the process of egg fertilization and formation within the chicken reproductive tract. Next, the most commonly used chick staging...
06:15
Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
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Cited by 11 •
2016
Endothelial cell mitochondria are critical to maintain blood-brain-barrier integrity. We introduce a protocol to measure bioenergetic function in cerebral vascular endothelial cells.
FAQs
Vasculogenesis establishes primitive vascular tubes from differentiating endothelial precursor cells, providing an initial framework during embryogenesis. Angiogenesis acts on that framework by extending and remodeling existing vessels through endothelial-cell sprouting, migration, and lumen formation. Distinguishing these processes helps explain how an early vascular network becomes an organized system capable of supporting developing tissues.
Endothelial precursor cells provide the cellular starting point for primitive vessel formation. As these cells differentiate, they assemble into vascular tubes during embryogenesis, creating an early network before later remodeling occurs. Their contribution connects cellular differentiation with the establishment of circulation and helps researchers examine how vascular structures first arise in developing organisms.
These coordinated activities allow existing vessels to expand and become organized rather than remaining as a primitive network. Sprouting extends the vascular system, migration positions endothelial cells within developing structures, and lumen formation creates the internal space needed for vessel function. Together, they support network maturation, tissue patterning, and the establishment of circulation.
Embryonic vascular development progresses from the formation of primitive tubes to the expansion and organization of a broader vessel network. This progression establishes circulation while aligning the vascular system with developing tissues. The resulting arrangement supports oxygen and nutrient delivery, waste removal, and tissue patterning, making vascular development a central process in biology.
This field provides a framework for investigating congenital vascular disorders, in which vascular development is abnormal, as well as vascular changes associated with tumor growth. It also informs research on wound healing and regenerative medicine. Comparing normal formation and remodeling with these contexts can reveal how vascular networks support or influence tissue outcomes.
Wound healing and regenerative medicine depend on understanding how vascular networks form, expand, and organize in relation to tissues. Developmental principles offer a biological context for examining these processes, especially endothelial sprouting, migration, and lumen formation. Such knowledge helps connect vascular network behavior with tissue support, repair, and efforts to restore functional structures.