Vascular System Formation
Vascular System Formation - Related Videos
11:18
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Cited by 29 •
2013
Here we report an experimental technique of fluorescence intravital microscopy to visualize heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. This microscopic technology will be valuable to study the molecular mechanism of vascular disease and to test pharmacologic agents under pathophysiological conditions.
04:44
Renal Organotypic Culture on Chicken CAM: A Technique for Transplantation of Murine Kidney Explants on Chicken CAM to Induce Formation of Renal Vascular Architecture
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2023
This video describes a method for studying organ development using an improved xenotransplantation setup on chorioallantoic membrane (CAM) from avian embryos. This method allows for the development of fully vascularized cultured embryonic organs and organoids.
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
02:16
Solution Formation
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2020
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride. This selective solubility...
FAQs
Vasculogenesis establishes primitive vessels when endothelial progenitor cells assemble, whereas angiogenesis expands and reorganizes that initial network by producing sprouts and branches from existing vessels. Considering both processes is important because vessel formation does not end with the first vessel structures; subsequent growth and remodeling help produce a connected system capable of supporting developing tissues.
Vascular endothelial growth factor acts as a developmental signal that helps guide vessel sprouting, branching, and remodeling. Its importance lies in coordinating network growth with changing tissue needs rather than simply increasing vessel number. Studying this signaling context helps researchers interpret how vascular patterns emerge during embryonic development and tissue growth.
Primitive vessels must be reorganized into a functional network, so formation includes more than initial endothelial assembly. Remodeling changes how vessels connect and arrange as the system develops, supporting transport across tissues. This step is particularly relevant when researchers examine whether developing or engineered tissue has achieved a stable, usable blood supply rather than isolated vessel structures.
These studies can clarify how embryonic tissues acquire blood-vessel networks, how vascular growth accompanies tissue expansion, and how developmental processes relate to vascular disease. Researchers can compare the sequence of endothelial assembly, sprouting, branching, and remodeling to understand which stages shape network organization and which changes may be associated with abnormal vascular development.
In regenerative medicine, vascular system formation provides a framework for addressing the need for blood supply in developing replacement or repaired tissues. Research focuses on how vessel networks arise and become organized, because tissue growth depends on effective transport. This knowledge can guide efforts to create tissues that develop a stable vascular connection rather than remaining poorly supplied.
Cancer biology uses vascular development as a context for understanding how blood-vessel growth relates to tissue behavior and disease. Engineered-tissue research applies the same principles to designing constructs that require an adequate blood supply. In both areas, studying vessel sprouting, branching, and remodeling helps evaluate how network organization influences tissue support and function.