Yellow Marrow
Yellow Marrow - Related Videos
01:18
Yellow Fever
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2026
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
03:56
Bone Marrow Aspiration: A Method to Obtain Bone Marrow to Examine Cell Morphology
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2023
This video describes the technique of aspirating bone marrow from iliac spine and smear preparation for biopsy. In the example, we perform bone marrow aspiration from an acute myeloid leukemia (AML) patient and examine the cells to check for measurable residual disease (MRD), an important prognostic biomarker.
07:06
Bone Marrow-derived Macrophage Production
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Cited by 205 •
2013
Macrophages have long been recognized as a critical component of the innate and adaptive immune responses. The recent explosion of knowledge pertaining to evolutionary, genetic, and biochemical aspects of the interaction between macrophages and microbes has renewed scientific attention to macrophages. This article describes a method to differentiate macrophages from mouse bone marrow.
08:42
Transplantation of Whole Kidney Marrow in Adult Zebrafish
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Cited by 17 •
2007
In this article, we demonstrate a method to perform HCT in adult zebrafish.
02:57
Bone Marrow-Derived Dendritic Cells Generation: A Method to Generate Dendritic Cells from Mouse Bone Marrow
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2023
This video describes a protocol for the generation of dendritic cells--key antigen-presenting cells that activate T cells--from the bone marrow of an adult mouse.
FAQs
During development, hematopoietic red marrow is progressively replaced by adipocytes within the medullary cavity. This shift changes the tissue toward lipid storage while preserving blood vessels and stromal cells that support the local microenvironment. The process alters marrow composition without eliminating the structural and supportive elements associated with skeletal tissue function.
Severe blood loss increases the demand for new blood cell production. In response, some yellow marrow can partially reconvert to red marrow and resume hematopoiesis, the formation of blood cells. This reversibility links marrow composition to physiological demand, allowing internal marrow spaces to participate again in blood formation when production needs rise.
Adipocytes provide the tissue’s main energy-storage component, whereas blood vessels and stromal cells help maintain the marrow microenvironment. Their coexistence means yellow marrow is not simply an inert fat deposit. It remains an organized skeletal tissue compartment whose cellular and vascular context can support changes in hematopoietic activity when physiological demand increases.
The medullary cavity provides an internal skeletal compartment where marrow composition can change while remaining connected to bone biology. Yellow marrow therefore links adipocyte-based energy storage with skeletal tissue function, and its reversible relationship with red marrow adds a blood-production dimension to the study of long bones.
Yellow marrow connects several research areas, including bone marrow development, energy metabolism, blood formation, aging, and disorders that alter marrow composition or function. Its value lies in linking these topics within one tissue system, especially through the relationship between adipocyte accumulation, preserved stromal and vascular support, and possible return to hematopoiesis.
Because marrow disorders can disrupt tissue composition or function, yellow marrow provides context for examining those changes alongside the normal red-to-yellow relationship. Its study can help biologists consider how altered adipocyte content, disrupted microenvironmental support, or reduced reversible hematopoietic capacity may influence overall marrow behavior.