Zebrafish Hematopoiesis
Zebrafish Hematopoiesis - Related Videos
01:21
Hematopoiesis
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2025
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
01:20
Overview of Hematopoiesis
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2024
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs). Developmental Phases of Hematopoiesis Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
11:50
Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
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Cited by 9 •
2012
A 3D culture system for hematopoiesis is described using human cord blood and leukemic bone marrow cells. The method is based on the use of a porous synthetic polyurethane scaffold coated with extracellular matrix proteins. This scaffold is adaptable to accommodate a wide range of cells.
08:42
Transplantation of Whole Kidney Marrow in Adult Zebrafish
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Cited by 17 •
2007
In this article, we demonstrate a method to perform HCT in adult zebrafish.
06:55
In vivo Electroporation of Morpholinos into the Adult Zebrafish Retina
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Cited by 42 •
2011
A method to conditionally knockdown a target protein’s expression in the adult zebrafish retina is described, which involves intravitreally injecting antisense morpholinos and electroporating them into the retina. The resulting protein is knocked down for several days, which allows testing the protein’s role in the regenerating or intact retina.
FAQs
Hematopoietic stem and progenitor cells originate in embryonic sites such as the posterior blood island and dorsal aorta, then relocate to the caudal hematopoietic tissue and kidney marrow. This sequential movement places developing cells in new environments that support blood-cell production and maintenance, making migration an important feature for studying vertebrate blood development.
Surrounding cellular niches regulate whether hematopoietic stem and progenitor cells self-renew or differentiate. Their signals therefore influence how the blood-forming system is maintained and how progenitors generate different blood-cell types. Examining these niche interactions helps researchers connect local tissue environments with stem-cell behavior and blood production in a living vertebrate.
Transparency allows investigators to observe blood-cell development and behavior directly in vivo, rather than relying only on observations from isolated or fixed material. This access is especially useful for examining where hematopoietic cells arise, how they migrate, and how blood-cell populations behave during embryogenesis, providing a visible connection between tissue location and developmental outcome.
Researchers can follow the locations and movements of hematopoietic cells as they pass from embryonic origins toward later blood-forming tissues. They can also examine blood-cell behavior in vivo and relate those observations to the generation of erythrocytes, leukocytes, and thrombocytes. These features make the model useful for connecting cell behavior with blood-system development.
The system provides an accessible setting for examining how genetic mutations or candidate drugs affect blood development and blood-cell behavior. Because embryonic processes can be observed in vivo, researchers can relate experimental changes to visible alterations in hematopoietic cell production or movement. Such studies support investigation of blood disorders and evaluation of potential biological effects.
Zebrafish hematopoiesis supports research on stem-cell biology, blood disorders, immunity, and drug effects. Its value comes from linking hematopoietic stem and progenitor-cell activity with the production of erythrocytes, leukocytes, and thrombocytes in a vertebrate organism. This combination allows broader biological questions to be examined alongside the development and maintenance of blood cells.