Cancer Signaling
Cancer Signaling - Related Videos
03:03
mTOR Signaling and Cancer Progression
0 Views •
2023
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors. The mTOR pathway or the...
03:03
mTOR Signaling and Cancer Progression
0 Views •
2021
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors. The mTOR pathway or the...
10:13
A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
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Cited by 6 •
2013
Achieving a systems level understanding of cellular processes is a goal of modern-day cell biology. We describe here strategies for multiplexing luciferase reporters of various cellular function end-points to interrogate gene function using genome-scale RNAi libraries.
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Cited by 5 •
2016
Integration of data from genome-wide sequencing experiments and metabolomics experiments is a challenge. In this paper we report, for the first time, generation, analysis and integration of transcriptome, cistrome and metabolome data from breast cancer cells treated with estradiol.
07:16
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Cited by 6 •
2014
The isolation of cancer stem cells (CSCs) directly from human tissues is requisite for their biological characterization. This manuscript describes a methodology for the isolation of prostate CSCs from human tissues, while also providing tips on troubleshooting difficult steps.
FAQs
Genetic or epigenetic changes can alter receptors, intracellular signaling proteins, or transcription factors so that pathway activity remains switched on. This persistent signaling can promote continued proliferation and help cells avoid normal apoptosis, the regulated process of cell death. Studying these alterations helps cancer researchers connect molecular changes with abnormal tumor behavior.
These components act at different stages of molecular communication. Receptors receive growth-related signals, intracellular signaling proteins transmit or amplify information inside the cell, and transcription factors influence gene activity. Changes at any of these levels can maintain signals that support cancer-cell growth or survival, making each component relevant for identifying disease mechanisms and therapeutic targets.
Persistent activity in growth, survival, or stress-response pathways can influence how cancer cells behave during treatment. Because Cancer Signaling regulates responses to treatment as well as proliferation and survival, pathway abnormalities may help explain why some tumors do not respond as expected. Examining these abnormalities can reveal mechanisms associated with treatment resistance.
These pathway groups illuminate different aspects of tumor biology. Growth factor signaling helps explain signals that promote cellular expansion, cell-cycle regulation reveals how proliferation is controlled, and stress responses show how cells react to challenging conditions. Considering them together gives cancer researchers a broader view of tumor behavior than examining a single pathway alone.
Researchers analyze relevant molecular pathways and the alterations affecting their components, including receptors, intracellular signaling proteins, and transcription factors. They may use this information to investigate disease mechanisms and identify biomarkers, measurable molecular features associated with a tumor. The resulting pathway profile can connect molecular abnormalities with growth, survival, or treatment response.
Pathway analysis can indicate which molecular abnormalities are associated with tumor growth, survival, or treatment response. These findings support the development of targeted therapies designed around disease-relevant signaling features and can help explain resistance when treatment is ineffective. In cancer research, the same knowledge contributes to more precise approaches for detecting and managing tumors.