Radiotracer Automation

Radiotracer automation is the use of programmed instruments and integrated workflows to produce, purify, and quality-check radioactive compounds for chemical and biomedical research. In an automated synthesis system, pumps, valves, reactors, and sensors coordinate the transfer of radioactive precursors through controlled reactions, followed by purification and formulation while minimizing operator exposure and managing short-lived materials. These workflows improve reproducibility, timing, and radiation safety in positron emission tomography (PET) tracer production and other radiochemistry applications. Automation also supports rapid method development, standardized quality control, and reliable preparation of tracers used to study biological processes, diagnose disease, and evaluate new medicines.

Radiotracer Automation - Related Videos

Research

JoVE Journal - Chemistry
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Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production

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Cited by 9 •

2018

Positron-emission tomography (PET) imaging sites that are involved in multiple early clinical research trials need robust and versatile radiotracer manufacturing capabilities. Using the radiotracer [18F]Clofarabine as an example, we illustrate how to automate the synthesis of a radiotracer using a flexible, cassette-based radiosynthesizer and validate the synthesis for clinical use.

Research

JoVE EoE - Neuroimaging

Positron Emission Tomography Imaging of the Human Brain Using a Radiotracer

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2025

Source: Jamadar, S. et. al. Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET. J. Vis. Exp. (2019)This video demonstrates the quantification of brain glucose metabolism using positron emission tomography (PET). The participant is infused with the tracer F-18 fluorodeoxyglucose (FDG) during scanning. FDG accumulates in active neurons and emits positrons upon F-18 decay. These positrons interact with electrons,...

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays

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Cited by 1 •

2016

Peptide adsorption to plasticware during traditional tip-based serial dilutions can significantly impact potency determination and confound the understanding of structure-activity relationships used for lead identification and lead optimization phases of drug discovery. Here methods for automated acoustic non-contact serial dilution of peptide samples are described.

FDG Based PET/CT Scan: A Method of Using Radiotracer for Non-invasive Imaging of Tumor Metabolism

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2023

This article describes multimodality imaging of cancerous tissues with PET and CT diagnostic imaging by using a radiotracer 18F-FDG. Cancerous tissue with high glycolytic activity uptakes more 18F-FDG.

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

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Cited by 3 •

2020

The synthesis of fluorine-18 (18F) labeled radiopharmaceuticals for positron emission tomography typically requires months of experience. When incorporated into a radiotracer, the silicon-fluoride acceptor (SiFA) motif enables a simple 18F-labeling protocol that is independent of costly equipment and preparatory training, while reducing precursor quantity needed and utilizing milder reaction conditions.

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