Brush Border
Brush Border - Related Videos
13:57
Preparation and Friction Force Microscopy Measurements of Immiscible, Opposing Polymer Brushes
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Cited by 4 •
2014
The methodology to perform friction force microscopy experiments for contacting brushes is presented: Two polymer brushes that are grafted from (a) substrates and (b) colloidal probes are slid to show that, by using two contacting immiscible brush systems, friction in sliding contacts is reduced compared to miscible brush systems.
06:56
Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions
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Cited by 17 •
2013
Poly(ethylene glycol) (PEG) brush-arm star polymers (BASPs) with narrow mass distributions and tunable nanoscopic sizes are synthesized in via ring opening metathesis polymerization (ROMP) of a PEG-norbornene macromonomer followed by transfer of portions of the resulting living brush initiator to vials containing varied amounts of a rigid, photo-cleavable bis-norbornene crosslinker.
10:25
Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
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Cited by 9 •
2019
Brush cells are rare cholinergic chemosensory epithelial cells found in the naïve mouse trachea. Due to their limited numbers, ex vivo evaluation of their functional role in airway immunity and remodeling is challenging. We describe a method for isolation of tracheal brush cells by flow cytometry.
09:03
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
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Cited by 7 •
2020
To guarantee a successful and high-quality ciliary functional analysis for PCD diagnosis, a precise and careful method for respiratory epithelium sampling and processing is essential. To continue providing PCD diagnostic service during the COVID-19 pandemic, the ciliary videomicroscopy protocol has been updated to include appropriate infection control measures.
10:09
Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
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Cited by 5 •
2018
Surface fabrication methods for patterned deposition of nanometer thick brushes or micron thick, crosslinked films of an azlactone block co-polymer are reported. Critical experimental steps, representative results, and limitations of each method are discussed. These methods are useful for creating functional interfaces with tailored physical features and tunable surface reactivity.
FAQs
The actin filament core provides an organized internal framework within each microvillus, while membrane proteins perform specialized surface tasks. Digestive enzymes act on intestinal contents, and transporters support movement of solutes across the epithelial surface. Their arrangement links structural organization to exchange, so brush-border performance depends on both the microvillar scaffold and its functional proteins.
Intestinal brush-border enzymes complete the breakdown of nutrients at the epithelial surface, immediately before those nutrients enter epithelial cells. This placement connects the final stage of digestion with uptake rather than treating them as separate events. Consequently, impaired brush-border activity can help explain poor nutrient absorption and related malabsorption concerns.
The small-intestinal brush border is associated with completing digestion and enabling nutrient entry into epithelial cells. In the kidney, the corresponding surface supports reabsorption, or recovery of solutes. The same structural specialization therefore has different physiological implications: intestinal dysfunction relates to malabsorption, whereas renal involvement provides context for kidney disorders.
A clinical interpretation can connect brush-border abnormalities with the function of the tissue in which they occur. In the intestine, injury or impaired function may help explain malabsorption because digestion and nutrient uptake are closely linked at the epithelial surface. The structure therefore provides a link between microscopic epithelial damage and impaired nutritional handling.
A tissue-based comparison is essential. In the small intestine, assessment centers on the relationship among brush-border enzymes, nutrient entry, and malabsorption. In the kidney, attention shifts to solute reabsorption and disorders affecting renal function. This comparison prevents one description of brush-border biology from being applied identically to both organs.
Brush-border examination connects microscopic organization with clinically meaningful function. Reviewing the actin-supported microvilli, surface enzymes, and transporters can clarify how epithelial cells handle digestion, nutrient uptake, or solute movement. In clinical physiology and pathology, that connection helps organize explanations of intestinal injury, malabsorption, and kidney disorders without separating structure from function.