Bubble Study

A bubble study is a clinical imaging technique that uses agitated saline as a temporary contrast agent to evaluate blood flow and detect abnormal connections between the heart chambers or vessels. During echocardiography, microbubbles are injected into a peripheral vein; they normally remain in the right-sided circulation and are filtered by the lungs, but their appearance in the left atrium can indicate a right-to-left shunt, such as a patent foramen ovale or atrial septal defect. The test helps investigate unexplained hypoxemia, stroke, or suspected intracardiac and pulmonary vascular shunts, supporting diagnosis and treatment planning.

Bubble Study - Related Videos

Education

JoVE Core - Physics

Excess Pressure Inside a Drop and a Bubble

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2023

The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops. where γ corresponds to the surface tension. Recalling that the force per...

Research

JoVE Journal - Engineering

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

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Cited by 2 •

2021

A fast and reliable technique is proposed to control the shape oscillations of a single, trapped acoustic bubble that is based on coalescence technique between two bubbles. The steady-state, symmetry-controlled bubble shape oscillations allow analysis of the fluid flow generated in the vicinity of the bubble interface.

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Cited by 8 •

2017

A microfluidic chip was fabricated to produce pairs of gold dots for tandem bubble generation and fibronectin-coated islands for single-cell patterning nearby. The resultant flow field was characterized by particle image velocimetry and was employed to study various bioeffects, including cell membrane poration, membrane deformation, and intracellular calcium response.

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

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Cited by 12 •

2019

Here, we present a protocol for the formation of lipid bilayers using a contact bubble bilayer method. A water bubble is blown into an organic solvent, whereby a monolayer is formed at the water-oil interface. Two pipettes are manipulated to dock the bubbles to form a bilayer.

Cultivation of Green Microalgae in Bubble Column Photobioreactors and an Assay for Neutral Lipids

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Cited by 23 •

2019

Here, we present a protocol to construct lab-scale bubble column photobioreactors and use them to culture microalgae. It also provides a method for the determination of the culture growth rate and neutral lipid content.

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