Collagen Vascular Diseases
Collagen Vascular Diseases - Related Videos
09:23
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
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Cited by 40 •
2015
In this work, we present a technique for the rapid fabrication of living vascular tissues by direct culturing of collagen, smooth muscle cells and endothelial cells. In addition, a new protocol for the mechanical characterization of engineered vascular tissues is described.
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cited by 25 •
2014
The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.
09:06
Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
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Cited by 7 •
2012
We describe a technique in which a section of the abdominal aorta from a mouse is transplanted orthotopically to just below the renal arteries in an allogeneic or syngeneic recipient. This technique can be useful in studies in which transplantation of large arteries of uniform size is deemed advantageous.
07:25
Collagen Hydrogels
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2023
Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...
07:03
Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Cited by 18 •
2014
This procedure demonstrates in vivo near IR fluorescence imaging of collagen remodeling activities in mice as well as ex vivo staining of collagens in tissue sections using caged collagen mimetic peptides that can be photo-triggered to hybridize with denatured collagen strands.
FAQs
Dysregulated immune responses can generate autoantibodies that target the body's own structures, while immune complexes may deposit within tissues. These processes promote inflammation and damage in collagen-rich connective tissues and vascular structures. Because the injury is immune mediated and systemic, clinical effects may appear in more than one organ rather than remaining confined to a single anatomical site.
The affected tissues and vessels determine the clinical pattern, so inflammation may involve the skin, joints, muscles, kidneys, lungs, or vascular structures in different combinations. This variation helps explain why related disorders can share systemic features yet present differently. Recognizing the distribution of organ involvement therefore contributes to clinical interpretation and comparison among possible diagnoses.
Differential diagnosis relies on the combined pattern of characteristic symptoms, laboratory findings, and affected organs rather than on one feature alone. Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, dermatomyositis, and Sjögren syndrome can therefore be evaluated by comparing their clinical and laboratory patterns. This approach supports a more specific interpretation of a patient's systemic inflammatory presentation.
Clinical evaluation brings together reported symptoms, examination of involved tissues, laboratory findings, and evidence of organ involvement. Follow-up then uses the same types of information to monitor whether disease activity or organ effects are changing over time. This structured assessment supports differential diagnosis, helps identify evolving systemic manifestations, and informs ongoing patient care.
Organ involvement is important when inflammation extends beyond the initially recognized symptoms, particularly when the skin, joints, muscles, kidneys, lungs, or vascular structures may be affected. Mapping these manifestations helps clinicians characterize the disease pattern, monitor systemic effects, and use the resulting information when considering treatment and longer-term care.
Research into the immune mechanisms underlying these disorders can clarify how autoantibodies, immune-complex deposition, and inflammation contribute to tissue injury. Those insights support development of targeted therapies rather than relying only on broad descriptions of symptoms. Better understanding of disease mechanisms may also improve monitoring strategies and contribute to more effective long-term patient care.