Pulmonary Function Test

Pulmonary function tests are a group of noninvasive measurements that assess how well the lungs move air, exchange gases, and support breathing, making them important tools in clinical evaluation. Spirometry records airflow and lung volumes during controlled inhalation and forced exhalation, while additional tests can measure diffusion of oxygen and carbon monoxide across the alveolar-capillary membrane or total lung capacity. Clinicians use these results to identify and characterize obstructive and restrictive patterns, evaluate symptoms such as breathlessness, monitor respiratory disease, and assess responses to treatment. Standardized testing also supports preoperative assessment and longitudinal tracking of pulmonary health.

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JoVE Core - Medical-Surgical Nursing

Pulmonary Function Tests

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2024

Pulmonary Function Tests (PFTs) Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy. PFTs involve using a spirometer, a...

Research

JoVE Journal - Medicine

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

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Cited by 22 •

2015

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

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2025

The presentation of detailed methods for the evaluation of right ventricle function will enhance the quality and reliability of pulmonary hypertension research, offering a robust framework for future studies and enhancing reproducibility across different laboratories.

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

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Cited by 34 •

2014

Right ventricle (RV) dysfunction is critical to the pathogenesis of cardiovascular disease, yet limited methodologies are available for its evaluation. Recent advances in ultrasound imaging provide a noninvasive and accurate option for longitudinal RV study. Herein, we detail a step-by-step echocardiographic method using a murine model of RV pressure overload.

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

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Cited by 8 •

2017

The following protocol describes the methodology for the acquisition and analysis of echocardiographic images used to obtain the Left Atrial Volume (LAV), Aorta (Ao) diameter, and Pulmonary Artery (PA) diameter in mice. This technique is a non-invasive, non-terminal procedure that allows assessment of the cardiopulmonary function.

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