Valvular Regurgitation

Valvular regurgitation is the backward leakage of blood through a heart valve that fails to close completely, reducing forward flow and increasing cardiac workload. It occurs when abnormal valve structure or function allows blood to return to the chamber it just left, such as during ventricular contraction or relaxation depending on the affected valve; chronic leakage can trigger chamber dilation and remodeling. In clinical practice, echocardiography helps identify the involved valve and assess regurgitation severity, while symptoms, ventricular response, and disease progression guide monitoring, medical management, or valve repair or replacement. Recognizing regurgitation early supports timely treatment and helps prevent heart failure.

Valvular Regurgitation - Related Videos

Research

JoVE Journal - Biology

Isolation of Valvular Endothelial Cells

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Cited by 82 •

2010

We provide a method for isolating and culturing pure populations of heart valve endothelial cells (VEC). VEC can be isolated from either side of the cusp or leaflet and immediately following, underlying interstitial cell (VIC) isolation is straightforward.

Isolation and Culture of Avian Embryonic Valvular Progenitor Cells

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Cited by 4 •

2010

This article will provide a method for isolating and culturing quail or chicken HH14- valve endocardial cells and HH25 valve cushion mesenchymal cells.

Education

JoVE Core - Medical-Surgical Nursing

Mitral Regurgitation I: Introduction

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2025

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

Aortic Regurgitation I: Introduction

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2025

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

Mitral Regurgitation IV: Nursing Management

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2025

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...

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