Internal Lung Volume
Internal Lung Volume - Related Videos
11:26
Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
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Cited by 1 •
2016
We present a protocol to assess the rate of alveolar fluid clearance or pulmonary edema in neonatal mouse lung using X-ray imaging technology.
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
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Cited by 47 •
2015
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
05:35
Lung Instillation and Fixation: Introducing Liquid into the Trachea and Fixing Lungs to Measure the Fixed Lung Volume
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2023
This video describes a simple and reliable method of introducing liquid into the trachea for lung instillation, fixation, and lung volume measurement.
08:46
A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
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Cited by 22 •
2017
Internal lung surface area (ISA) is a critical criterion for assessing lung morphology and physiology in lung diseases and injury-induced alveolar regeneration. We describe here a standardized method that can minimize the measurement bias for ISA in both lung pneumonectomy and prosthesis implantation mouse models.
06:16
Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
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2015
We describe a novel technique for heterotopic abdominal heart-lung transplantation (HAHLT) in rats. The transplant configuration results in a partially loaded graft circulation, allowing direct functional assessment. This model may be employed for acute or chronic studies of function and immunologic status of the transplanted graft.
FAQs
Contraction of the diaphragm and intercostal muscles changes thoracic pressure, which alters the amount of air contained within the lungs. These pressure changes drive airflow during the respiratory cycle, so muscle activity links mechanical movement of the thorax with measurable changes in lung volume. Examining this relationship helps connect respiratory function with pulmonary development.
These volume components describe different aspects of respiratory capacity rather than a single undifferentiated measurement. Tidal volume reflects air associated with the respiratory cycle, whereas residual and vital volumes provide additional information about air remaining in the lungs and usable respiratory capacity. Considering them separately can clarify how developmental changes or impairment affect pulmonary function.
Tracking internal lung volume from fetal life through adulthood provides a functional view of pulmonary maturation. Changes in measured volumes can be considered alongside the developing respiratory system to characterize how breathing capacity progresses over time. This approach also helps distinguish typical developmental patterns from alterations associated with impaired lung development or other experimental conditions.
An altered measurement may indicate a difference in pulmonary development, respiratory function, or the effects of disease or an experimental intervention. Because internal lung volume reflects the interaction between thoracic pressure changes and airflow, it offers more than a structural observation. Its interpretation can help assess whether gas-exchange capacity is developing or functioning as expected.
Researchers track lung volumes across developmental stages to relate changing respiratory capacity to pulmonary maturation. Measurements can be compared across fetal life, later development, and adulthood, or examined after an intervention. The resulting profile helps characterize functional outcomes, including whether altered development is associated with reduced respiratory capacity or changes relevant to gas exchange.
Interpretation should account for the point in the respiratory cycle because air content changes as diaphragm and intercostal muscle contractions alter thoracic pressure. It is also important to identify which volume component is being considered, such as tidal, residual, or vital volume. These distinctions support clearer comparisons of development, disease effects, and experimental outcomes.