Aggregate Interface
Aggregate Interface - Related Videos
02:04
Protein-protein Interfaces
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2020
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
10:10
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
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Cited by 29 •
2009
The platelet adhesion cascade takes place in the presence of shear flow, a factor not accounted for in conventional (static) well-plate assays. This article reports on a platelet-aggregation assay utilizing a microfluidic well-plate format to emulate physiological shear flow conditions.
10:10
Aggregates for Concrete and Asphaltic Mixes
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2023
Source: Roberto Leon, Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA Concrete and asphalt are by far the most common construction materials used today. Concrete is a composite material consisting of cement, water, air, coarse aggregate, and fine aggregates. Fine aggregates are typically sands and coarse aggregates are natural or crushed rocks. Chemical admixtures to modify certain specific properties are also commonly used (i.e., superplasticizers to make the...
04:12
An In Vitro Technique to Study Antimicrobial Treatments on Bacterial Aggregates
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2025
This video demonstrates an in vitro technique to study the impact of antimicrobial treatment on Pseudomonas aeruginosa (Pa) aggregates. Fluorescently-labeled Pa cells are grown as aggregates, mimicking the growth pattern during infection. Upon challenging the aggregates with a sublethal concentration of the antibiotic colistin, the real-time assessment of the bacteria-antibiotic interaction is performed via fluorescence microscopy.
11:57
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Cited by 7 •
2017
The goal of the method presented here is to explore protein aggregation during normal aging in the model organism C. elegans. The protocol represents a powerful tool to study the highly insoluble large aggregates that form with age and to determine how changes in proteostasis impact protein aggregation.
FAQs
Adhesion binds the aggregate surface to the surrounding binder, while friction resists sliding and mechanical interlock transfers load through surface irregularities. Together, these mechanisms influence whether stress is transferred effectively or whether movement develops along the boundary. Examining their relative contribution helps explain differences in composite strength, stiffness, and damage resistance.
When aggregate and matrix differ in stiffness or porosity, the interface can experience localized stress concentrations. Those concentrations make the boundary important in understanding how cracking begins or damage progresses, rather than treating the composite as uniform. Engineers therefore consider material compatibility at the interface when seeking improved structural performance and durability.
The interfacial transition zone is the region that develops between aggregate and matrix, and its condition affects how the two materials interact under load. Considering this zone alongside adhesion, texture, friction, and interlock gives a more complete explanation of interface-controlled behavior in particulate composites, including changes in cracking, moisture resistance, and durability.
A useful assessment considers adhesion, surface texture, friction, mechanical interlock, and the interfacial transition zone, while also noting stiffness and porosity differences between phases. Relating these features to strength, stiffness, cracking, moisture resistance, and durability helps engineers identify which interface characteristics require improvement and supports more informed material selection.
Characterization connects observed interface properties with practical mixture decisions. Engineers can use the results to select compatible aggregate and matrix materials, optimize mixture design, and interpret why a composite has failed or degraded. This connection turns interface observations into design guidance for improving performance and developing more reliable infrastructure or other composite systems.
In concrete, asphalt, and other particulate composites, interface-focused analysis helps explain variations in strength, stiffness, cracking, moisture resistance, and durability. Its value is both diagnostic and preventive: engineers can use it to interpret damage mechanisms and guide optimization when selecting or refining materials for infrastructure and related composite applications.