Brain Tumor Segmentation
Brain Tumor Segmentation - Related Videos
03:45
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This video demonstrates the application of Tumor Treating Fields or TTFields in human brain tumor models. This non-invasive technique delivers low-intensity alternating electric fields directly to the brain, resulting in inhibition of cell division and subsequent apoptosis.
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02:46
Establishing a Brain Tumor in an Organotypic Slice Co-culture Model
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This video demonstrates the development of a 3D co-culture system. Mouse brain slices are placed on a membrane, and fluorescently labeled human brain tumor cells are allowed to grow on it. Once the system is ready, it is stained for imaging.
08:02
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
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Cited by 9 •
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The purpose of this article is to describe the use of an orthotopic glioblastoma model for chemoradiation studies. This article will go though cell processing, implanting, and radiotherapy of the mouse using an intracranial model.
07:02
Blood-Brain Tumor Barrier or BBTB Model: An Adaption of the Blood-Brain Barrier or BBB Model to Evaluate Delivery of Therapeutics to the Tumor
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2023
In this video, we describe a comprehensive protocol to establish an in vitro model mimicking the blood-brain tumor barrier. The model holds promise to understand the delivery of therapeutic agents for the treatment of brain tumors.
FAQs
Segmentation algorithms can evaluate image intensity, texture, contrast, and spatial patterns together rather than relying on a single visual feature. These characteristics provide complementary information about how tissue appears and where it is located relative to surrounding brain structures. Combining them supports more precise classification of image regions and helps produce a clinically useful tumor boundary or volume.
The analysis may classify individual pixels in image slices or three-dimensional voxels throughout an MRI volume. Voxel-based processing represents the tumor as a spatial structure rather than as separate, unrelated regions on each slice. This distinction matters when estimating tumor volume and preserving the boundary’s continuity across the imaged brain.
Both approaches can classify image regions, but they represent different engineering strategies for interpreting MRI data. Image-processing algorithms use defined operations on features such as intensity, texture, contrast, or spatial pattern, whereas machine-learning models perform classification through a learned computational approach. The resulting output can be evaluated as a tumor boundary or volume.
Accuracy affects the reliability of quantitative measurements derived from the segmented region, including the estimated tumor volume. More accurate boundaries can support treatment planning, surgical guidance, and comparison of tumor changes over time. In engineering research, accuracy also matters when assessing computer-assisted diagnostic systems or comparing automated results with manual annotations.
A typical workflow begins with MRI data and analyzes relevant image characteristics, including intensity, texture, contrast, and spatial patterns. An algorithm or machine-learning model then classifies pixels or three-dimensional voxels. The classified regions are converted into a tumor boundary or volume, which can subsequently support measurement, planning, guidance, or monitoring.
Automated segmentation is useful when researchers need quantitative tumor measurements or must process data more efficiently than manual annotation allows. The generated boundary or volume can provide structured information for analysis while reducing the time required to outline regions by hand. Manual annotations remain relevant as a comparison point when evaluating the performance of computer-assisted diagnostic systems.
The output provides a measurable representation of tumor extent that can be incorporated into treatment planning and surgical guidance. It also supports tumor characterization by converting image information into a defined region or volume. These outputs help biomedical engineers develop systems that connect medical imaging analysis with clinical decision-support and procedure-related tasks.
Applying the analysis to imaging obtained at different times can produce tumor boundaries or volumes for longitudinal comparison. Changes in these measurements may help characterize how the tumor’s imaged extent varies during monitoring. In biomedical engineering, this use connects segmentation with systems designed to organize quantitative imaging information across time rather than relying only on a single scan.