Kondo Blockade

Kondo blockade is a mesoscopic transport phenomenon in which many-body interactions suppress electrical conductance through a nanoscale device, reversing the usual conductance enhancement associated with the Kondo effect. It occurs when a localized electron spin couples to conduction electrons and, in systems such as coupled quantum dots, coherent transport pathways interfere destructively, preventing transmission near the Kondo resonance. Studying Kondo blockade helps engineers understand electron correlations, phase coherence, and spin-dependent transport in quantum devices. These insights support the design of quantum dots, molecular electronics, and spintronic components with controllable current and interference-based functionality.

Kondo Blockade - Related Videos

Education

JoVE Core - Pharmacology

Neuromuscular Junction And Blockade

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2025

The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...

Research

JoVE Journal - Medicine

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy

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Cited by 49 •

2013

This article presents a method for measuring the working abdominal volume during laproscopic myomectomy using the surgical grasper, and applies this technique to obtain pilot data on whether deep neuromuscular blockade (NMB) can enable the use of lower insufflation pressure. Reduced insufflation pressure during laproscopic surgery has been shown to reduce post-operative pain, and thus the use of NMB during surgery may enable improved patient outcomes.

Research

JoVE Journal - Immunology and Infection
Free Sample

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Cited by 9 •

2011

This paper describes a simple technique to induce alloantigen-specific anergy in human peripheral blood mononuclear cells. The technique can be applied clinically to generate non-alloreactive donor cells. Infusion of these cells could improve immune reconstitution and reduce toxicity after allogeneic hematopoietic stem cell transplantation.

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

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Cited by 1 •

2023

Checkpoint inhibitors are important targets in developing therapies for the battle against cancer. This report introduces a novel PDL1 peptide-based cancer vaccine, PDL1-Vaxx, which induces neutralizing polyclonal antibody production that blocks PD-1/PDL1 complex formation. This work also details the development and testing of a fluorescent bead-based assay for analyzing this activity.

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

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Cited by 87 •

2011

A method to expand γδ T cells from peripheral blood mononuclear cells (PBMC) is described. PBMC-derived γδ T cells are stimulated and expanded using zoledronate and interleukin-2 (IL-2). Large scale expansion of γδ T cells can be applied to autologous cellular immunotherapy of cancer.

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